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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 5608287, 12 pages
Research Article

Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes

1Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA
2Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC, USA
3LipoScience, Laboratory Corporation of America Holdings, Morrisville, NC, USA
4Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, NC, USA
5Division of Cardiology Medicine, Duke University Medical Center, Durham, NC, USA

Correspondence should be addressed to David B. Bartlett

Received 23 February 2017; Revised 11 April 2017; Accepted 24 April 2017; Published 31 May 2017

Academic Editor: Patricia C. Brum

Copyright © 2017 David B. Bartlett et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA in persons at risk for type 2 diabetes. GlycA, fitness, and body habitus were measured in 169 sedentary adults (45–75 years) with prediabetes randomly assigned to one of four six-month exercise-based lifestyle interventions. Interventions included exercise prescription based on the amount (energy expenditure (kcal/kg weight/week (KKW)) and intensity (%VO2peak). The groups were (1) low-amount/moderate-intensity (10KKW/50%) exercise; (2) high-amount/moderate-intensity (16KKW/50%) exercise; (3) high-amount/vigorous-intensity (16KKW/75%) exercise; and (4) a Clinical Lifestyle (combined diet plus low-amount/moderate-intensity exercise) intervention. Six months of exercise training and/or diet-reduced GlycA (mean Δ: −6.8 ± 29.2 μmol/L; ) and increased VO2peak (mean Δ: 1.98 ± 2.6 mL/kg/min; ). Further, visceral (mean Δ: −21.1 ± 36.6 cm2) and subcutaneous fat (mean Δ: −24.3 ± 41.0 cm2) were reduced, while liver density (mean Δ: +2.3 ± 6.5HU) increased, all . When including individuals in all four interventions, GlycA reductions were associated with reductions in visceral adiposity (). Exercise-based lifestyle interventions reduced GlycA concentrations through mechanisms related to exercise-induced modulations of visceral adiposity. This trial is registered with Clinical Trial Registration Number NCT00962962.