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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 6405278, 9 pages
Research Article

Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression

1Bastyr University Research Institute, 14500 Juanita Dr. NE, Kenmore, WA 98028, USA
2Oregon State University, 101 Milam Hall, Corvallis, OR 97331, USA

Correspondence should be addressed to Laurie K. Mischley; ude.rytsab@yelhcsiml

Received 11 April 2017; Revised 19 July 2017; Accepted 30 July 2017; Published 10 September 2017

Academic Editor: Anna M. Giudetti

Copyright © 2017 Laurie K. Mischley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression. Methods. The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake. In this cross-sectional analysis, regression analysis was performed on baseline data to identify the nutritional and pharmacological interventions associated with the rate of PD progression. All analyses were adjusted for age, gender, and years since diagnosis. Results. 1053 individuals with self-reported idiopathic PD were available for analysis. Foods associated with the reduced rate of PD progression included fresh vegetables, fresh fruit, nuts and seeds, nonfried fish, olive oil, wine, coconut oil, fresh herbs, and spices (). Foods associated with more rapid PD progression include canned fruits and vegetables, diet and nondiet soda, fried foods, beef, ice cream, yogurt, and cheese (). Nutritional supplements coenzyme Q10 and fish oil were associated with reduced PD progression ( and , resp.), and iron supplementation was associated with faster progression (). Discussion. These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression.