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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 6838921, 6 pages
Research Article

Identification of Patients Affected by Mitral Valve Prolapse with Severe Regurgitation: A Multivariable Regression Model

1Centro Cardiologico Monzino IRCCS, Milan, Italy
2Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
3Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy

Correspondence should be addressed to Paolo Poggio; ti.mfcc@oiggop.oloap

Received 8 September 2016; Revised 30 December 2016; Accepted 11 January 2017; Published 2 February 2017

Academic Editor: Cecilia Zazueta

Copyright © 2017 Paola Songia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. Besides echocardiography, up to now there are no reliable biomarkers available for the identification of this pathology. We aim to generate a predictive model, based on circulating biomarkers, able to identify MVP patients with the highest accuracy. Methods. We analysed 43 patients who underwent mitral valve repair due to MVP and compared to 29 matched controls. We assessed the oxidative stress status measuring the oxidized and the reduced form of glutathione by liquid chromatography-tandem mass spectrometry method. Osteoprotegerin (OPG) plasma levels were measured by an enzyme-linked immunosorbent assay. The combination of these biochemical variables was used to implement several logistic regression models. Results. Oxidative stress levels and OPG concentrations were significantly higher in patients compared to control subjects ( versus and versus  pg/mL, respectively; ). The best regression model was able to correctly classify 62 samples out of 72 with accuracy in terms of area under the curve of 0.92. Conclusions. To the best of our knowledge, this is the first study to show a strong association between OPG and oxidative stress status in patients affected by MVP with severe regurgitation.