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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7317251, 9 pages
Research Article

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

1Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
3Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer’s Prevention & Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
4Department of Pathology, University of Washington, Seattle, WA, USA
5Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA

Correspondence should be addressed to Anthony J. A. Molina; ude.htlaehekaw@aniloma

Received 30 March 2017; Revised 9 June 2017; Accepted 20 July 2017; Published 2 October 2017

Academic Editor: Maik Hüttemann

Copyright © 2017 Daniel J. Tyrrell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer’s disease. In this study of nonhuman primates, we focus on mitochondrial function and bioenergetic capacity assessed by the respirometric profiling of monocytes, platelets, and frontal cortex mitochondria. Our data indicate that differences in the maximal respiratory capacity of brain mitochondria are reflected by CD14+ monocyte maximal respiratory capacity and platelet and monocyte bioenergetic health index. A subset of nonhuman primates also underwent [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to assess brain glucose metabolism. Our results indicate that platelet respiratory capacity positively correlates to measures of glucose metabolism in multiple brain regions. Altogether, the results of this study provide early evidence that blood-based bioenergetic profiling is related to brain mitochondrial metabolism. While these measures cannot substitute for direct measures of brain metabolism, provided by measures such as FDG-PET, they may have utility as a metabolic biomarker and screening tool to identify individuals exhibiting systemic bioenergetic decline who may therefore be at risk for the development of neurodegenerative diseases.