RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene

Figure 1

RTA-408 conserved renal function at 24 h reperfusion. (a) Chemical structure of triterpenoid RTA-408. 24 hours before sham or I/R surgery, RTA-408 (100 μg/kg body weight) or vehicle (0.1% DMSO in PBS) was administered intraperitoneally. (b) Serum creatinine level of the sham + vehicle group () and sham + RTA-408 group () at 24 h, 72 h, and 7 d reperfusion. (c, d) Serum creatinine and blood urea nitrogen of blood sample collected at 24 h reperfusion from the sham-operated group (sham, ), vehicle-treated I/R group (vehicle + I/R, ), and RTA-408-treated I/R group (408 + I/R, ). Data were presented as mean ± SD. Significant difference versus the vehicle + I/R group (Figure 1(c), ; Figure 1(d), ).

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