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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8361493, 13 pages
https://doi.org/10.1155/2017/8361493
Research Article

A Chilean Berry Concentrate Protects against Postprandial Oxidative Stress and Increases Plasma Antioxidant Activity in Healthy Humans

1Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile
2Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad de Talca, 3460000 Talca, Chile

Correspondence should be addressed to Ines Urquiaga; lc.cup.oib@agaiuqrui

Received 23 September 2016; Revised 5 November 2016; Accepted 23 November 2016; Published 24 January 2017

Academic Editor: Maura Palmery

Copyright © 2017 Ines Urquiaga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Leighton, G. Polic, P. Strobel et al., “Health impact of Mediterranean diets in food at work,” Public Health Nutrition, vol. 12, no. 9, pp. 1635–1643, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Urquiaga, G. Echeverria, G. Polic et al., “Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases,” World Review of Nutrition and Dietetics, vol. 98, pp. 150–173, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. I. Urquiaga, P. Strobel, D. Perez et al., “Mediterranean diet and red wine protect against oxidative damage in young volunteers,” Atherosclerosis, vol. 211, no. 2, pp. 694–699, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Jiménez-Aspee, C. Theoduloz, F. Ávila et al., “The Chilean wild raspberry (Rubus geoides Sm.) increases intracellular GSH content and protects against H2O2 and methylglyoxal-induced damage in AGS cells,” Food Chemistry, vol. 194, pp. 908–919, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Gobert, D. Rémond, M. Loonis, C. Buffière, V. Santé-Lhoutellier, and C. Dufour, “Fruits, vegetables and their polyphenols protect dietary lipids from oxidation during gastric digestion,” Food and Function, vol. 5, no. 9, pp. 2166–2174, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Jung, S. Triebel, T. Anke, E. Richling, and G. Erkel, “Influence of apple polyphenols on inflammatory gene expression,” Molecular Nutrition and Food Research, vol. 53, no. 10, pp. 1263–1280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Annuzzi, L. Bozzetto, G. Costabile et al., “Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial,” The American Journal of Clinical Nutrition, vol. 99, no. 3, pp. 463–471, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. C. L. Ellis, I. Edirisinghe, T. Kappagoda, and B. Burton-Freeman, “Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake. A randomized placebo-controlled trial,” Journal of Atherosclerosis and Thrombosis, vol. 18, no. 4, pp. 318–327, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Gorelik, M. Ligumsky, R. Kohen, and J. Kanner, “A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products,” The FASEB Journal, vol. 22, no. 1, pp. 41–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Sirota, S. Gorelik, R. Harris, R. Kohen, and J. Kanner, “Coffee polyphenols protect human plasma from postprandial carbonyl modifications,” Molecular Nutrition and Food Research, vol. 57, no. 5, pp. 916–919, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Peluso, H. Manafikhi, R. Reggi, Y. Longhitano, C. Zanza, and M. Palmery, “Relationship between the peroxidation of leukocytes index ratio and the improvement of postprandial metabolic stress by a functional food,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 5630985, 10 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Avila, G. Echeverria, D. Perez et al., “Serum ferritin is associated with metabolic syndrome and red meat consumption,” Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 769739, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Holvoet, J. Vanhaecke, S. Janssens, F. Van de Werf, and D. Collen, “Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease,” Circulation, vol. 98, no. 15, pp. 1487–1494, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Holvoet, D. Collen, and F. Van de Werf, “Malondialdehyde-modified LDL as a marker of acute coronary syndromes,” The Journal of the American Medical Association, vol. 281, no. 18, pp. 1718–1721, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Vassalle, N. Botto, M. G. Andreassi, S. Berti, and A. Biagini, “Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease,” Coronary Artery Disease, vol. 14, no. 3, pp. 213–218, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Del Rio, A. J. Stewart, and N. Pellegrini, “A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 15, no. 4, pp. 316–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Cheng, F. Wang, D.-F. Yu, P.-F. Wu, and J.-G. Chen, “The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons,” European Journal of Pharmacology, vol. 650, no. 1, pp. 184–194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. R. J. Bloomer, M. M. Kabir, K. E. Marshall, R. E. Canale, and T. M. Farney, “Postprandial oxidative stress in response to dextrose and lipid meals of differing size,” Lipids in Health and Disease, vol. 9, article 79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. K. H. Fisher-Wellman and R. J. Bloomer, “Exacerbated postprandial oxidative stress induced by the acute intake of a lipid meal compared to isoenergetically administered carbohydrate, protein, and mixed meals in young, healthy men,” Journal of the American College of Nutrition, vol. 29, no. 4, pp. 373–381, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Perez-Martinez, J. M. Garcia-Quintana, E. M. Yubero-Serrano et al., “Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study,” Clinical Science, vol. 119, no. 6, pp. 251–261, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Khor, R. Grant, C. Tung et al., “Postprandial oxidative stress is increased after a phytonutrient-poor food but not after a kilojoule-matched phytonutrient-rich food,” Nutrition Research, vol. 34, no. 5, pp. 391–400, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. R. J. Bloomer and K. H. Fisher-Wellman, “Lower postprandial oxidative stress in women compared with men,” Gender Medicine, vol. 7, no. 4, pp. 340–349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. R. J. Bloomer, D. E. Ferebee, K. H. Fisher-Wellman, J. C. Quindry, and B. K. Schilling, “Postprandial oxidative stress: influence of sex and exercise training status,” Medicine & Science in Sports & Exercise, vol. 41, no. 12, pp. 2111–2119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. R. J. Bloomer, A. D. Solis, K. H. Fisher-Wellman, and W. A. Smith, “Postprandial oxidative stress is exacerbated in cigarette smokers,” British Journal of Nutrition, vol. 99, no. 5, pp. 1055–1060, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. R. J. Bloomer, B. Cole, and K. H. Fisher-Wellman, “Racial differences in postprandial oxidative stress with and without acute exercise,” International Journal of Sport Nutrition and Exercise Metabolism, vol. 19, no. 5, pp. 457–472, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. R. J. Bloomer and K. H. Fisher-Wellman, “Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal,” Oxidative Medicine and Cellular Longevity, vol. 2, no. 1, pp. 19–25, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Devaraj, J. Wang-Polagruto, J. Polagruto, C. L. Keen, and I. Jialal, “High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome,” Metabolism: Clinical and Experimental, vol. 57, no. 6, pp. 867–870, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Cardona, I. Túnez, I. Tasset, L. Garrido-Sánchez, E. Collantes, and F. J. Tinahones, “Circulating antioxidant defences are decreased in healthy people after a high-fat meal,” British Journal of Nutrition, vol. 100, no. 2, pp. 312–316, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Camargo, O. A. Rangel-Zúñiga, P. Peña-Orihuela et al., “Postprandial changes in the proteome are modulated by dietary fat in patients with metabolic syndrome,” Journal of Nutritional Biochemistry, vol. 24, no. 1, pp. 318–324, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Roberts, S. Magwenzi, A. Aburima, and K. M. Naseem, “Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade,” Blood, vol. 116, no. 20, pp. 4297–4306, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Hu, G. Block, E. P. Norkus, J. D. Morrow, M. Dietrich, and M. Hudes, “Relations of glycemic index and glycemic load with plasma oxidative stress markers,” The American Journal of Clinical Nutrition, vol. 84, no. 1, pp. 70–76, 2006. View at Google Scholar
  32. S. Gorelik, M. Ligumsky, R. Kohen, and J. Kanner, “The stomach as a ‘bioreactor’: when red meat meets red wine,” Journal of Agricultural and Food Chemistry, vol. 56, no. 13, pp. 5002–5007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Kanner, S. Gorelik, S. Roman, and R. Kohen, “Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: the stomach as a bioreactor,” Journal of Agricultural and Food Chemistry, vol. 60, no. 36, pp. 8790–8796, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Speisky, C. López-Alarcón, M. Gómez, J. Fuentes, and C. Sandoval-Acuña, “First web-based database on total phenolics and oxygen radical absorbance capacity (ORAC) of fruits produced and consumed within the south andes region of South America,” Journal of Agricultural and Food Chemistry, vol. 60, no. 36, pp. 8851–8859, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Miranda-Rottmann, A. A. Aspillaga, D. D. Pérez, L. Vasquez, A. L. F. Martinez, and F. Leighton, “Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress,” Journal of Agricultural and Food Chemistry, vol. 50, no. 26, pp. 7542–7547, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. N. F. Gordon, M. Gulanick, F. Costa et al., “Physical activity and exercise recommendations for stroke survivors,” Circulation, vol. 109, no. 16, pp. 2031–2041, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. National Institute of Health, 1998, https://www.nhlbi.nih.gov/news/press-releases/1998/first-federal-obesity-clinical-guidelines-released.
  38. C. A. Burtis and E. R. Ashwood, Eds., Tietz Textbook of Clinical Chemistry, WB Saunders Company, Philadelphia, Pa, USA, 1994.
  39. G. Cao, H. M. Alessio, and R. G. Cutler, “Oxygen-radical absorbance capacity assay for antioxidants,” Free Radical Biology and Medicine, vol. 14, no. 3, pp. 303–311, 1993. View at Publisher · View at Google Scholar · View at Scopus
  40. I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the fRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
  41. V. L. Singleton and J. A. Rossi, “Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents,” American Journal of Enology and Viticulture, vol. 16, no. 3, pp. 144–158, 1965. View at Google Scholar
  42. J. Lee, R. W. Durst, and R. E. Wrolstad, “Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study,” Journal of AOAC International, vol. 88, no. 5, pp. 1269–1278, 2005. View at Google Scholar · View at Scopus
  43. M.-H. Salagoïty-Auguste and A. Bertrand, “Wine phenolics—analysis of low molecular weight components by high performance liquid chromatography,” Journal of the Science of Food and Agriculture, vol. 35, no. 11, pp. 1241–1247, 1984. View at Publisher · View at Google Scholar
  44. A. S. Csallany, M. Der Guan, J. D. Manwaring, and P. B. Addis, “Free malonaldehyde determination in tissues by high-performance liquid chromatography,” Analytical Biochemistry, vol. 142, no. 2, pp. 277–283, 1984. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Hagstromer, P. Oja, and M. Sjostrom, “The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity,” Public Health Nutrition, vol. 9, no. 6, pp. 755–762, 2006. View at Google Scholar
  46. B. R. Day, D. R. Williams, and C. A. Marsh, “A rapid manual method for routine assay of ascorbic acid in serum and plasma,” Clinical Biochemistry, vol. 12, no. 1, pp. 22–26, 1979. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Templar, S. P. Kon, T. P. Milligan, D. J. Newman, and M. J. Raftery, “Increased plasma malondialdehyde levels in glomerular disease as determined by a fully validated HPLC method,” Nephrology Dialysis Transplantation, vol. 14, no. 4, pp. 946–951, 1999. View at Publisher · View at Google Scholar · View at Scopus
  48. R. L. Levine, J. A. Williams, E. R. Stadtman, and E. Shacter, “Carbonyl assays for determination of oxidatively modified proteins,” Methods Enzymol, vol. 233, pp. 346–357, 1994. View at Google Scholar
  49. J. Chrzczanowicz, A. Gawron, A. Zwolinska et al., “Simple method for determining human serum 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity—possible application in clinical studies on dietary antioxidants,” Clinical Chemistry and Laboratory Medicine, vol. 46, no. 3, pp. 342–349, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Boeing, A. Bechthold, A. Bub et al., “Critical review: vegetables and fruit in the prevention of chronic diseases,” European Journal of Nutrition, vol. 51, no. 6, pp. 637–663, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. B. Nguyen, A. Bauman, J. Gale, E. Banks, L. Kritharides, and D. Ding, “Fruit and vegetable consumption and all-cause mortality: evidence from a large Australian cohort study,” The International Journal of Behavioral Nutrition and Physical Activity, vol. 13, article 9, 2016. View at Publisher · View at Google Scholar · View at Scopus
  52. R. H. Liu, “Health-promoting components of fruits and vegetables in the diet,” Advances in Nutrition, vol. 4, no. 3, pp. 384S–392S, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. M. S. Fernández-Pachón, G. Berná, E. Otaolaurruchi, A. M. Troncoso, F. Martín, and M. C. García-Parrilla, “Changes in antioxidant endogenous enzymes (activity and gene expression levels) after repeated red wine intake,” Journal of Agricultural and Food Chemistry, vol. 57, no. 15, pp. 6578–6583, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Szajdek and E. J. Borowska, “Bioactive compounds and health-promoting properties of berry fruits: a review,” Plant Foods for Human Nutrition, vol. 63, no. 4, pp. 147–156, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Ruiz, I. Hermosín-Gutiérrez, C. Mardones et al., “Polyphenols and antioxidant activity of calafate (Berberis microphylla) fruits and other native berries from Southern Chile,” Journal of Agricultural and Food Chemistry, vol. 58, no. 10, pp. 6081–6089, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Ruiz, I. Hermosín-Gutiérrez, C. Vergara et al., “Anthocyanin profiles in south Patagonian wild berries by HPLC-DAD-ESI-MS/MS,” Food Research International, vol. 51, no. 2, pp. 706–713, 2013. View at Publisher · View at Google Scholar · View at Scopus
  57. O. Inami, I. Tamura, H. Kikuzaki, and N. Nakatani, “Stability of anthocyanins of Sambucus canadensis and Sambucus nigra,” Journal of Agricultural and Food Chemistry, vol. 44, no. 10, pp. 3090–3096, 1996. View at Publisher · View at Google Scholar · View at Scopus
  58. I. Urquiaga and F. Leighton, “Polifenoles del Vino,” in Dietas Mediterraneas, La Evidencia Científica, chapter 8, pp. 113–128, Pontificia Universidad Católica de Chile, 2004. View at Google Scholar
  59. K. Tetsuya, M. Seiichi, H. Yoshihiko, and I. Takashi, Reactivity of Anthocyanin toward Reactive Oxygen and Reactive Nitrogen Species, Molecular Interventions in Lifestyle-Related Diseases, CRC Press, 2005.
  60. U.S. Department of Agriculture. Agricultural Research Service, Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release 2, Nutrient Data Laboratory, 2010, http://www.orac-info-portal.de/download/ORAC_R2.pdf.
  61. L. Vávrová, J. Kodydková, M. Zeman et al., “Altered activities of antioxidant enzymes in patients with metabolic syndrome,” Obesity Facts, vol. 6, no. 1, pp. 39–47, 2013. View at Publisher · View at Google Scholar
  62. F. N. Ahmed, F. N. Naqvi, and F. Shafiq, “Lipid peroxidation and serum antioxidant enzymes in patients with type 2 diabetes mellitus,” Annals of the New York Academy of Sciences, vol. 1084, no. 1, pp. 481–489, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. J. Schrezenmeir, S. Fenselau, I. Keppler et al., “Postprandial triglyceride high response and the metabolic syndrome,” Annals of the New York Academy of Sciences, vol. 827, pp. 353–368, 1997. View at Publisher · View at Google Scholar · View at Scopus
  64. K. H. Park, K. J. Kim, B.-W. Lee, E. S. Kang, B. S. Cha, and H. C. Lee, “The effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients,” Acta Diabetologica, vol. 51, no. 1, pp. 15–22, 2014. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Kanner and T. Lapidot, “The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants,” Free Radical Biology and Medicine, vol. 31, no. 11, pp. 1388–1395, 2001. View at Publisher · View at Google Scholar · View at Scopus
  66. P. Holvoet, G. Perez, Z. Zhao, E. Brouwers, H. Bernar, and D. Collen, “Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease,” The Journal of Clinical Investigation, vol. 95, no. 6, pp. 2611–2619, 1995. View at Publisher · View at Google Scholar · View at Scopus
  67. J. W. Baynes and S. R. Thorpe, “Glycoxidation and lipoxidation in atherogenesis,” Free Radical Biology and Medicine, vol. 28, no. 12, pp. 1708–1716, 2000. View at Publisher · View at Google Scholar · View at Scopus
  68. P. C. Burcham and Y. T. Kuhan, “Introduction of carbonyl groups into proteins by the lipid peroxidation product, malondialdehyde,” Biochemical and Biophysical Research Communications, vol. 220, no. 3, pp. 996–1001, 1996. View at Publisher · View at Google Scholar · View at Scopus
  69. R. Pamplona, “Advanced lipoxidation end-products,” Chemico-Biological Interactions, vol. 192, no. 1-2, pp. 14–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. C. Miglio, I. Peluso, A. Raguzzini et al., “Antioxidant and inflammatory response following high-fat meal consumption in overweight subjects,” European Journal of Nutrition, vol. 52, no. 3, pp. 1107–1114, 2013. View at Publisher · View at Google Scholar · View at Scopus
  71. C.-M. Wong, L. Marcocci, D. Das et al., “Mechanism of protein decarbonylation,” Free Radical Biology and Medicine, vol. 65, pp. 1126–1133, 2013. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Fernández-Iglesias, H. Quesada, S. Díaz et al., “Combination of grape seed proanthocyanidin extract and docosahexaenoic acid-rich oil increases the hepatic detoxification by GST mediated GSH conjugation in a lipidic postprandial state,” Food Chemistry, vol. 165, pp. 14–20, 2014. View at Publisher · View at Google Scholar · View at Scopus
  73. K. Yama, K. Sato, N. Abe, Y. Murao, R. Tatsunami, and Y. Tampo, “Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells,” Redox Biology, vol. 4, pp. 87–96, 2015. View at Publisher · View at Google Scholar · View at Scopus
  74. H. K. Bayele, E. S. Debnam, and K. S. Srai, “Nrf2 transcriptional derepression from Keap1 by dietary polyphenols,” Biochemical and Biophysical Research Communications, vol. 469, no. 3, pp. 521–528, 2016. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Ahotupa, J.-P. Suomela, T. Vuorimaa, and T. Vasankari, “Lipoprotein-specific transport of circulating lipid peroxides,” Annals of Medicine, vol. 42, no. 7, pp. 521–529, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. B. Burton-Freeman, “Postprandial metabolic events and fruit-derived phenolics: a review of the science,” British Journal of Nutrition, vol. 104, supplement 3, pp. S1–S14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  77. F. Natella, A. Ghiselli, A. Guidi, F. Ursini, and C. Scaccini, “Red wine mitigates the postprandial increase of LDL susceptibility to oxidation,” Free Radical Biology and Medicine, vol. 30, no. 9, pp. 1036–1044, 2001. View at Publisher · View at Google Scholar · View at Scopus
  78. L. Di Renzo, A. Carraro, R. Valente, L. Iacopino, C. Colica, and A. De Lorenzo, “Intake of red wine in different meals modulates oxidized LDL level, oxidative and inflammatory gene expression in healthy people: a randomized crossover trial,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 681318, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  79. J. E. Brown and M. F. Kelly, “Inhibition of lipid peroxidation by anthocyanins, anthocyanidins and their phenolic degradation products,” European Journal of Lipid Science and Technology, vol. 109, no. 1, pp. 66–71, 2007. View at Publisher · View at Google Scholar · View at Scopus
  80. N. P. Seeram and M. G. Nair, “Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins,” Journal of Agricultural and Food Chemistry, vol. 50, no. 19, pp. 5308–5312, 2002. View at Publisher · View at Google Scholar · View at Scopus
  81. G. Mazza, C. D. Kay, T. Cottrell, and B. J. Holub, “Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects,” Journal of Agricultural and Food Chemistry, vol. 50, no. 26, pp. 7731–7737, 2002. View at Publisher · View at Google Scholar · View at Scopus
  82. E. Abuin, E. Lissi, P. Ortiz, and C. Henriquez, “Uric acid reaction with DPPH radicals at the micellar interface,” Boletín de la Sociedad Chilena de Química, vol. 47, no. 2, pp. 145–149, 2002. View at Google Scholar · View at Scopus
  83. R. B. Pereira, C. Sousa, A. Costa, P. B. Andrade, and P. Valentão, “Glutathione and the antioxidant potential of binary mixtures with flavonoids: synergisms and antagonisms,” Molecules, vol. 18, no. 8, pp. 8858–8872, 2013. View at Publisher · View at Google Scholar · View at Scopus
  84. J. H. O'Keefe, N. M. Gheewala, and J. O. O'Keefe, “Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health,” Journal of the American College of Cardiology, vol. 51, no. 3, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  85. F. Natella, A. MacOne, A. Ramberti et al., “Red wine prevents the postprandial increase in plasma cholesterol oxidation products: a pilot study,” British Journal of Nutrition, vol. 105, no. 12, pp. 1718–1723, 2011. View at Publisher · View at Google Scholar · View at Scopus