Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects
IL-1β released by monocytes obtained from diabetic patients () and control subjects (). (a) Basal conditions. (b) After stimulation with LPS (1 μg/mL). Dot plots show individual absolute values measured in the culture medium at different glucose concentrations: glucose 2.5 mmol/L, 5.0 mmol/L, and 20 mmol/L. Graphs are completed with box plots, where the ends of the box represent the 25th and 75th quantiles, respectively, while the horizontal line within the box represents the median value; whiskers extend the distances computed as 1st quartile − 1.5 × interquartile range and 3rd quartile + 1.5 × interquartile range. Following a significant two-way ANOVA, comparisons between glucose concentrations have been evaluated as paired data (see Table 2 for detailed statistics). No significant differences were detected with one-way ANOVA between controls and diabetic patients at each glucose concentration.
We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at firstname.lastname@example.org to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.