Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects

Figure 1

IL-1β released by monocytes obtained from diabetic patients () and control subjects (). (a) Basal conditions. (b) After stimulation with LPS (1 μg/mL). Dot plots show individual absolute values measured in the culture medium at different glucose concentrations: glucose 2.5 mmol/L, 5.0 mmol/L, and 20 mmol/L. Graphs are completed with box plots, where the ends of the box represent the 25th and 75th quantiles, respectively, while the horizontal line within the box represents the median value; whiskers extend the distances computed as 1st quartile − 1.5 × interquartile range and 3rd quartile + 1.5 × interquartile range. Following a significant two-way ANOVA, comparisons between glucose concentrations have been evaluated as paired data (see Table 2 for detailed statistics). No significant differences were detected with one-way ANOVA between controls and diabetic patients at each glucose concentration.

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