Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42
Table 2
Zoometric and metabolic parameters to define metabolic syndrome.
NCD
HCD
value
Zoometric panel
Weight (g)
337 ± 2.9
397 ± 4.8
0.0002
Abdominal perimeter (cm)
17.1 ± 0.2
18.8 ± 0.04
0.0002
Body mass index
0.9 ± 0.01
1.21 ± 0.02
<0.0001
Lee index
34.3 ± 0.1
39.5 ± 0.21
<0.0001
Lipid panel
FFA (mg/dL)
2.21 ± 0.04
5.17 ± 0.11
<0.0001
Triglycerides (mg/dL)
71.1 ± 1.9
105.8 ± 2.6
<0.0001
Total cholesterol (mg/dL)
102.8 ± 9.1
99.5 ± 9.3
0.8666
Cholesterol subfractions
VLDL-chol (mg/dL)
14.4 ± 1.2
21.2 ± 2.9
0.9108
LDL-chol (mg/dL)
20.3 ± 4
45.4 ± 3.5
0.0001
HDL-chol (mg/dL)
68.1 ± 2
32.9 ± 5.5
0.0002
OGTT (1.75 g/kg)
Glucose fasting (mg/dL)
90 ± 4.3
108 ± 4.3
0.009
Glucose 30 min (mg/dL)‡
129.5 ± 3.3
168 ± 8.4
0.0012
Glucose 60 min (mg/dL)‡
100.4 ± 2.9
155.7 ± 6.6
0.0002
Glucose 90 min (mg/dL)‡
91.5 ± 4.0
123.9 ± 5.4
0.0014
AUC glucose (mg/dL/90 min)
320.7 ± 3.6
439 ± 6.2
<0.0001
Insulin curve
Insulin fasting (μUI/mL)
9.0 ± 1.1
18 ± 3.2
0.0054
Insulin 30 min (μUI/mL)‡
21.2 ± 2.8
56 ± 3.1
0.0002
Insulin 60 min (μUI/mL)‡
13.9 ± 1.4
32.3 ± 1.8
0.0001
Insulin 90 min (μUI/mL)‡
11.5 ± 1.0
25.8 ± 2.2
0.0003
AUC insulin (μUI/mL/90 min)
45.4 ± 1.8
110.2 ± 2.7
<0.0001
HOMA-IR
1.17 ± 0.05
2.4 ± 0.3
0.0003
HOMA-S%
85.8 ± 3.2
41.7 ± 1.7
<0.0001
The results of zoometric and serum parameters are represented as the average of 20 separate experiments ± SEM. and indicate a significant difference between HCD and NCD groups with by the nonparametric Wilcoxon test. ‡Values obtained after an oral glucose tolerance test (OGTT, 1.75 g of glucose/kg body weight). FFA: free fatty acid; VLDL: very-low-density lipoprotein; LDL: low-density lipoprotein; HDL: high-density lipoprotein; AUC: area under curve; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-S%: homeostasis model assessment of insulin sensitivity percentage. Table 2 is reproduced from Treviño et al. [23].
