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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 1630751, 9 pages
Research Article

Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice

1Research Unit of Macromolecular Biochemistry and Genetic, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia
2Common Services Unit for Research, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia
3Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia

Correspondence should be addressed to Ilhem Rjeibi; rf.oohay@iibiejr

Received 21 April 2018; Accepted 1 August 2018; Published 5 September 2018

Academic Editor: Renata Szymanska

Copyright © 2018 Ilhem Rjeibi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study was designed to assess the protective effects of Lycium europaeum methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a significant antioxidant activity in vitro on DPPH radical and H2O2 scavenging assays. In the animal studies, treatment with LEM significantly reduced the effects of cisplatin intoxication on serum liver biomarkers and serum renal biomarkers. Meanwhile, LEM diminishes significantly the effect of cisplatin on the level of lipid peroxidation in liver and kidney tissues. The activities of the antioxidant enzymes (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were increased in groups pretreated with LEM and quercetin. Additionally, the normal histological structures of the liver and kidney were restored after treatment with LEM. This work clearly demonstrated that L. europaeum may be useful as a drug with hepato-nephroprotective potentials.