Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2018 / Article

Corrigendum | Open Access

Volume 2018 |Article ID 3136860 | https://doi.org/10.1155/2018/3136860

Xian Wen Tan, Mrinal Bhave, Alan Yean Yip Fong, Eiji Matsuura, Kazuko Kobayashi, Lian Hua Shen, Siaw San Hwang, "Corrigendum to “Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes”", Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 3136860, 3 pages, 2018. https://doi.org/10.1155/2018/3136860

Corrigendum to “Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes”

Received19 Nov 2017
Accepted28 Nov 2017
Published22 Jan 2018

In the article titled “Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes” [1], errors in statistical analyses for inhibitory concentration (IC50) have resulted in incorrect tabulations of data for both Tables 2 and 4. The corrected versions of both tables are as below.


BJLNMR219
Log (dose)
(μg/mL)
Dose
(μg/mL)
Log (dose)
(μg/mL)
Dose
(μg/mL)

Day 1
(24 hours)
1.808 ± 0.01164.271.980 ± 0.01395.56
Day 2
(48 hours)
1.775 ± 0.00259.572.047 ± 0.026111.40
Day 3
(72 hours)
1.800 ± 0.00463.102.033 ± 0.029108.00


Average IC50 of H2O2 (μM)
Log [H2O2]H2O2

Control sample
 Negative control (media + 1% EtOH)2.433 ± 0.040271.00
RBE
 BJLN (25 μg/mL)2.776 ± 0.028597.20
 BJLN (50 μg/mL)1.954 ± 0.03389.95
 MR219 (50 μg/mL)2.561 ± 0.035364.20
 MR219 (100 μg/mL)2.158 ± 0.032143.90

Accordingly, in the “Results” (Section 3.1), the text reading “Based on the results (Table 2), the IC50 values of RBE of BJLN were in the range of 61.67 to 64.57 μg/mL over 24, 48, and 72 hours of incubation time.” should be corrected to “Based on the results (Table 2), the IC50 values of RBE of BJLN were in the range of 59.57 to 64.27 μg/mL over 24, 48, and 72 hours of incubation time.”, and “Based on the results, the IC50 values of MR219 RBE were in the range of 95.44 to 111.50 μg/mL over the three different incubation periods (Table 2).” should be corrected to “Based on the results, the IC50 values of MR219 RBE were in the range of 95.56 to 111.40 μg/mL over the three different incubation periods (Table 2).

In addition, in the “Results” (Section 3.3), the text reading “The positive effects were more distinctive with lower concentrations of RBE (BJLN: 25 μg/mL; MR219: 50 μg/mL) with observable increments in IC50 of H2O2 (BJLN: 645.65 μM; MR219: 320.63 μM) (Table 4) when compared to negative control (316.23 μM). When the two extracts were compared, BJLN (25 μg/mL) extract outran MR219 (50 μg/mL) extract in terms of efficacy with a significant increment in IC50 of H2O2 approximately twofold (645.65 μM) versus 1.4% (in approximation) when compared to negative control (316.23 μM).” should be replaced with “The positive effects were more distinctive with lower concentrations of RBE (BJLN: 25 μg/mL; MR219: 50 μg/mL) with observable increments in IC50 of H2O2 (BJLN: 597.20 μM; MR219: 364.20 μM) (Table 4) when compared to negative control (271.00 μM). When the two extracts were compared, BJLN (25 μg/mL) extract outran MR219 (50 μg/mL) extract in terms of efficacy with a significant increment in IC50 of H2O2 by approximately 2-fold (597.20 μM) versus 1.4-fold (in approximation) when compared to negative control (271.00 μM).”, and the text reading “Significant decrements in the IC50 values of H2O2 were found for cell pretreated with 50 μg/mL BJLN (92.90 μM) and 100 μg/mL MR219 (171.79 μM) extracts when compared to negative control (316.23 μM) (Table 4). The higher concentrations of BJLN and MR219 extracts selected were near the range of IC50 of both extracts (IC50 of BJLN: 52.18 μg/mL to 73.09 μg/mL; IC50 of MR219: 95.44 μg/mL to 111.50 μg/mL).” should be replaced with “Significant decrements in the IC50 values of H2O2 were found for cell pretreated with 50 μg/mL BJLN (89.95 μM) and 100 μg/mL MR219 (143.90 μM) extracts when compared to negative control (271.00 μM) (Table 4). The higher concentrations of BJLN and MR219 extracts selected were near the range of IC50 of both extracts (IC50 of BJLN: 59.57 μg/mL to 64.27 μg/mL; IC50 of MR219: 95.56 μg/mL to 111.40 μg/mL).”

An incorrect version of Figure 3 with missing graphical elements was published. The corrected version of Figure 3 with the inclusion of graphical elements is as shown below.

Accordingly, Figure 5(b) presented in the original manuscript was also the incorrect version. The fourth datum point for MR219 (50 μg/mL) (grey dotted line) was incorrectly plotted. The correct version of the figure is as shown below with the corrected fourth datum point for MR219 (50 μg/mL) (grey dotted line).

References

  1. X. W. Tan, M. Bhave, A. Y. Y. Fong et al., “Cytoprotective and cytotoxic effects of rice bran extracts in rat H9c2(2-1) cardiomyocytes,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 6943053, 12 pages, 2016. View at: Publisher Site | Google Scholar

Copyright © 2018 Xian Wen Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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