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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 8575263, 12 pages
https://doi.org/10.1155/2018/8575263
Review Article

The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis

Faculty of Medical & Health Sciences, Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland, New Zealand

Correspondence should be addressed to Andrea J. Braakhuis; zn.ca.dnalkcua@siuhkaarb.a

Received 21 February 2018; Revised 24 April 2018; Accepted 3 May 2018; Published 12 July 2018

Academic Editor: Ilaria Peluso

Copyright © 2018 Andrea J. Braakhuis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), ), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), ), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), ). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging.