MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling

Figure 7

Possible working model of MHY2233 in preventing senescence in EPCs: possible mechanism of MHY2233 to prevent vascular senescence in EPCs. MHY2233 increases SIRT1 activity and, upon aging or stress, increases the activity of FOXO3a, which translocates into the nucleus and upregulates the expression of SIRT1. SIRT1 increases the activity of eNOS and reduces the ROS levels by producing nitric oxide. Similarly, SIRT1 downregulates the SASPs and p16^ink4a and reduces EPC senescence. Moreover, SIRT1 activity deacetylates p53 and downregulates the expression of p21, thereby reducing EPC senescence.