Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD

Figure 3

The effect on the gut microbiota structure of SLBZS. (a–d) Rarefaction curves showing microbial richness based on the Chao1 index and microbial richness and evenness on the Shannon index. (e, f) Microbiome clustering based on unweighted principal component analysis (PCA) and principal coordinate analysis (PCoA) UniFrac metrics of fecal gut microbiota. (g, h) Unweighted UniFrac distance and unweighted pair-group method with arithmetic means (UPGMA) showed that DSS and SLBZS treatment can separate rats clearly. Statistical significant difference was assessed through one-way ANOVA with LSD post hoc test , , and ; .

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