Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage

Figure 1

High-fat diet induces glycolipid metabolic abnormalities and damages the reproductive function of male mice. (a) Comparison of the time-dependent changes in body weight between the normal-diet-fed (N) and high-fat-diet-fed (H) groups during the 8 weeks of feeding. (b) Representative picture of normal-diet and high-fat-diet mice on the 8th week. Comparison of testicular weights (c) and epididymal adipose tissue (d) in the N and H groups on the 8th week. The serum glucose (e), biochemical parameters (f), and FSH levels (g) were assayed on the 8th week. for each group. Comparison of fertility, including the fertility rate (h), number of pups per litter (i), and average pup weight (j) on the 8th week of feeding in the N and H groups. For the fertility assay, males were included in each group. The results are presented as the . and vs. the corresponding N group.

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