Mechanisms of Anthracycline-Enhanced Reactive Oxygen Metabolism in Tumor Cells

Table 3

Effect of anthracycline antibiotics on superoxide production by the tumor microsomal fraction. Superoxide production in tumor microsomes was determined as described in Table 2. For these studies, all drugs were present at a concentration of 135 μM.

Drug	Superoxide formation (nmol/min/mg)
Daunorubicin	(5)^a,b
Rubidazone	(6)^b
Aclacinomycin A	(3)^b
5-Iminodaunorubicin	(3)

^a.; number in parentheses is number of experiments performed; ^bsignificantly higher than the control rate of superoxide formation in tumor microsomes (; Table 2).