Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction

Figure 1

Changes in expression for mitochondrial energy metabolism-related genes between insulin resistance and insulin resistance+sodium butyrate (NaB) treatment groups. (a–c) Changes for genes related to mitochondrial energy metabolism were assayed by the RT² Profiler PCR Array; (a) volcano plot for log2 fold changes in genes between groups; (b) relative expression comparison for genes between high insulin (-axis) and high insulin+NaB treatment (-axis) groups; (c) fold changes in gene expression for twenty representative genes after NaB administration. (d) Predicted protein-protein interaction among genes from mitochondrial energy metabolism and genes with NaB activity generated from the STRING database.

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