Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 2 / Research Article
Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction Table 2 Expression of mitochondrial energy metabolism-related genes between insulin resistance (insulin) and insulin resistance+sodium butyrate (NaB/insulin) treatment groups.
Gene Accession no. Normalized ratio (insulin+NaB/insulin) Up/downregulation ATP12A NM_001185085.1 1.2014 0.0531 — ATP4A NM_000704.3 0.1417 0.0006 Down ATP4B NM_000705.4 0.0654 0.0004 Down ATP5A1 NM_001001935.3 0.4648 0.1675 Down ATP5B NM_001686.4 0.2171 0.0001 Down ATP5C1 NM_001001973.3 0.0827 0.0004 Down ATP5F1 NM_001688.5 0.6247 0.0002 — ATP5G1 NM_005175.3 1.1209 0.4700 — ATP5G2 NM_001330269.1 0.1045 <0.0001 Down ATP5G3 NM_001190329.2 0.0006 <0.0001 Down ATP5H NM_006356.3 0.3197 0.0593 Down ATP5I NM_007100.4 0.0655 <0.0001 Down ATP5J NM_001003703.1 3.1998 0.0354 Up ATP5J2 NM_004889.5 9.8811 0.0006 Up ATP5L NM_006476.5 0.5051 <0.0001 — ATP5O NM_001697.3 0.6247 0.0002 — ATP6V0A2 NM_012463.4 0.6408 0.0006 — ATP6V0D2 NM_152565.1 0.6247 0.0002 — ATP6V1C2 NM_001039362.2 2.5339 0.0187 Up ATP6V1E2 NM_001318063.2 0.5028 0.0212 Down ATP6V1G3 NM_001320218.1 1.2351 0.5168 — BCS1L NM_001079866.2 0.7551 0.8782 — COX4I1 NM_001861.6 0.6543 0.1425 — COX4I2 NM_032609.3 13.1592 <0.0001 Up COX5A NM_004255.4 0.7621 0.0348 — COX5B NM_001862.3 1.3146 0.3899 — COX6A1 NM_004373.4 0.0004 <0.0001 Down COX6A2 NM_005205.4 2.7473 0.0264 Up COX6B1 NM_001863.5 0.0837 <0.0001 Down COX6B2 NM_001369798.1 0.0006 <0.0001 Down COX6C NM_004374.4 0.6320 0.0003 Down COX7A2 NM_001865.4 22.0800 0.0001 Up COX7A2L NM_004718.4 0.0008 <0.0001 Down COX7B NM_001866.3 0.7817 0.0019 — COX8A NM_004074.3 5.4945 0.0001 Up COX8C NM_182971.3 3.6587 <0.0001 Up CYC1 NM_001916.5 0.0004 <0.0001 Down LHPP NM_022126.4 0.6247 0.0002 — NDUFA1 NM_004541.4 1.3579 0.0354 — NDUFA10 NM_001322019.1 0.6247 0.0002 — NDUFA11 NM_001193375.2 0.7745 0.0059 — NDUFA2 NM_002488.5 2.2212 0.0970 — NDUFA3 NM_004542.4 1.2757 0.0033 — NDUFA4 NM_002489.4 2.8706 <0.0001 — NDUFA5 NM_001291304.1 0.6247 0.0002 — NDUFA6 NM_002490.6 2.8050 0.0002 Up NDUFA7 NM_005001.5 0.6758 0.0504 — NDUFA8 NM_001318195.2 7.9521 0.0023 Up NDUFAB1 NM_005003.3 19.8537 0.0002 Up NDUFB10 NM_004548.3 73.5847 0.0001 Up NDUFB2 NM_004546.3 0.0001 0.0001 Down NDUFB3 NM_001257102.2 0.0657 0.0044 Down NDUFB4 NM_001168331.2 0.0005 0.0001 Down NDUFB5 NM_002492.4 0.0008 <0.0001 Down NDUFB6 NM_002493.5 0.8693 0.0576 — NDUFB7 NM_004146.6 0.0003 <0.0001 Down NDUFB8 NM_005004.4 0.5351 0.1035 — NDUFB9 NM_005005.3 0.0035 0.0001 Down NDUFC1 NM_001184986.1 0.0473 0.0001 Down NDUFC2 NM_004549.6 0.3450 <0.0001 Down NDUFS1 NM_005006.7 0.6176 0.0039 — NDUFS2 NM_004550.4 0.0031 <0.0001 Down NDUFS3 NM_004551.3 0.6247 0.0002 — NDUFS4 NM_002495.4 0.3749 <0.0001 Down NDUFS5 NM_004552.3 0.6247 0.0002 — NDUFS6 NM_004553.6 0.1052 <0.0001 Down NDUFS7 NM_024407.5 2.1856 0.0002 Up NDUFS8 NM_002496.4 0.6247 0.0002 — NDUFV1 NM_007103.4 0.0424 <0.0001 Down NDUFV2 NM_021074.5 23.3389 <0.0001 Up NDUFV3 NM_021075.4 0.1932 <0.0001 Down OXA1L NM_005015.5 0.0301 0.0001 Down PPA1 NM_021129.4 0.5502 0.0019 — PPA2 NM_176869.3 0.0111 <0.0001 Down SDHA NM_004168.4 0.1832 0.0008 Down SDHB NM_003000.3 26.9336 <0.0001 Up SDHC NM_003001.5 0.0785 0.0005 Down SDHD NM_003002.4 2.8905 <0.0001 Up UQCR11 NM_006830.4 5.6752 0.0049 Up UQCRC1 NM_003365.3 90.3843 <0.0001 Up UQCRC2 NM_003366.4 0.1332 0.0119 Down UQCRFS1 NM_006003.3 4.9178 <0.0001 Up UQCRH NM_006004.4 1.8506 <0.0001 — UQCRQ NM_014402.5 0.0390 <0.0001 Down
