New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and In Vitro Antiproliferative Activities on Breast and Prostate Human Cancer Cells
Table 3
(μM) values of 16–28 on DU-145 (prostate cancer cells) and MCF-7 (mammary cancer cells) and nontumorigenic HEK-293 (embryonic kidney cells).
Compound no.
R
DU-145
MCF-7
Mean value
HEK-293
16
C3H7
77.8 ± 1.1
>100
-
51.1 ± 0.8
17
C5H11
>100
>100
-
77.4 ± 0.6
18
4-MeOPh
>100
>100
-
>100
19
2,5-(OMe)2Ph
>100
>100
-
>100
20
2-Furyl
36.5 ± 0.2
>100
-
35.1 ± 1.4
21
2-Thienyl
53.1 ± 5.0
>100
-
67.6 ± 2.5
22
CH3
12.3 ± 0.4
21.2 ± 0.3
16.7
28.6 ± 1.9
23
C3H7
22.5 ± 0.2
23.3 ± 0.5
22.9
21.5 ± 0.7
24
C5H11
54.6 ± 1.5
>100
-
58.4 ± 0.6
25
4-MeOPh
>100
73.5 ± 1.6
-
71.3 ± 1.2
26
2,5-(OMe)2Ph
28.7 ± 0.7
74.1 ± 2.4
51.4
53.3 ± 1.2
27
2-Furyl
13.2 ± 1.1
21.2 ± 1.4
17.2
11.2 ± 0.7
28
2-Thienyl
24.8 ± 0.3
33.1 ± 1.6
28.9
22.9 ± 0.7
DOX
-
0.70 ± 0.02
0.05 ± 0.003
-
4.27 ± 0.34
Cells were incubated at 37°C for 48 h, with or without quinone derivatives. Afterwards, aliquots of cell suspensions were taken and the MTT test was performed, as described in Materials and Methods. Results are expressed as (). DOX = doxorubicin.