Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-κB Pathway

Figure 10

miR-34a antagomir attenuates NF-κB activity and inflammatory cytokine secretion in mice. (a, b) Translocation of the p65 subunit from the cytoplasm into the nucleus was evaluated by immunofluorescence (). Blue spots represent cell nuclei, and red spots represent p-p65 staining; or 20 μm. (c) Effect of in vivo injection of miR-34a antagomir on the mRNA levels of IL-1β, IL-6, and TNF-α in the uterus. Data analysis as in Figure 9.

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