The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low-Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta-Analysis

Table 1

Studies measuring ox-LDL included in the meta-analysis.

Author, year, country	Design of study	Follow-up	Type of surgery	Control ()	Outcome		Patients’ characteristic; Age; Sex	No. of patients
					ox-LDL methods of ox-LDL assessment	BMI change (%)
Carmona-Maurici et al., 2020 [24]; Spain	Prospective observational cohort study	6 months; 12 months	Laparoscopic RYGB or SG	—	Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	-32.27	Obese patients with atheromatous plaque; years old; 18 (F)/14 (M)	32
						-33.91	Obese patients without atheromatous plaque; years old; 29 (F)/5 (M)	34
Ho et al., 2021 [25]	Prospective, observational study	6 months; 12 months	RYGB, SG, or omega loop bypass	Patients seeking weight management [16]	Unchanged; (Mercodia ox-LDL kit)	-29.95	Morbid obesity patients; years old; -	59
Coimbra et al., 2019 [26]	Observational study	13 months	Laparoscopic adjustable gastric banding (LAGB)	Healthy volunteers [17]	Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	-11.85	Obese patients; years old; 18 (F)/2 (M)	20
Gomez-Martin et al., 2018 [27]	Observational study	6 months; 12 months	SG	Women matched for age and cardiovascular risk (modified Mediterranean diet); [18]	Significant decrease in ox-LDL levels after 12 months in comparison to baseline and control group; (Mercodia ox-LDL kit)	-28.83	Obese women; years old	20
			Laparoscopic RYGB			-33.82	Obese women; years old	20
Kelly et al., 2016 [28]	Longitudinal cohort	6 months; 12 months	RYGB or vertical SG	—	Significant decrease in ox-LDL levels at 12 months; (Mercodia ox-LDL kit)	-32.6	Adolescents with severe obesity; years old; 10 (M)/29 (F)	39
		3 months; 12 months	Laparoscopic RYGB	—	Unchanged; (Mercodia ox-LDL kit)	-35.6	Adolescents with severe obesity; years old; 3 (M)/10 (F)	13
Müller-Stich et al., 2015 [29]	Prospective cohort	6 months; 12 months	RYGB	—	Unchanged; (OxiSelect MDA-LDL-quantitation kit)	-25	Patients with BMI more than 35 kg/m^2 and insulin-dependent T2DM; years old; 10 (M)/10 (F)	20
Van der Schueren et al., 2015 [30]	Observational study	4 months; 7 years	Laparoscopic RYGB	Lean controls; [24]	Significant decrease in ox-LDL levels at 7 years; (Mercodia ox-LDL kit)	-26.6	Obese patients; years old; 5 (M)/12 (F)	17
Julve et al., 2014 [31]	Observational study	6 months; 12 months	RYGB	—	Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	—	Obese patients; 20-60 years old; 15 (F)/6 (M)	21
Martín-Rodríguez et al., 2014 [32]	Prospective cohort	12 months	Bariatric surgery	Lean; Control subjects; [30]	Significant decrease in ox-LDL levels (immunodiagnostic system)	-31.37	Obese patients without metabolic syndrome; years old; 19(F)/4(M)	23
						-16.33	Obese patients with metabolic syndrome; years old; 34(F)/5(M)	39
Garrido-Sánchez et al., 2008 [33]	Observational study	7 months	Biliopancreatic diversion, or RYGB	Healthy, nonobese persons; [11]	Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	-33.9	Morbidly obese patients with:	21
							Normal fasting glucose; years old; 14(F)/7(M)
						-30.39	Impaired fasting glucose; years old; 21(F)/10(M)	31
						-30.74	Type 2 diabetes; years old; 14(F)/7(M)	21
Uzun et al., 2004 [34]	Observational study	6 months	Open Swedish adjustable gastric band (SAGB)		Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	-24.24	Morbidly obese patients; years old; 10(F)/10(M)	20
			Laparoscopic SAGB	—	Significant decrease in ox-LDL levels; (Mercodia ox-LDL kit)	-24.27	Morbidly obese patients; years old; 11(F)/9(M)	20