Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells

Figure 9

Scheme of the mechanisms. Knockdown of VHL gene in HK-2 cells induces LCN2 overexpression and ROS accumulation, leading to inflammation with increased p-JNK/JNK ratio, p65 nuclear translocation, and macrophage chemotaxis. The results reveal the regulatory effect of VHL on inflammation in HK-2 cells via the LCN2-ROS pathway.