Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

Figure 6

Electrostatic similarity of human cytosolic thioredoxins and thioredoxin domain-containing proteins. The tree of electrostatic similarity (on top) was prepared as described in [14]. The first row shows the isosurfaces of the electrostatic potential at ±1 in blue (positive) and red (negative), respectively. The second row shows the electrostatic potential mapped to the water accessible surface at ±4 . The third row displays the cartoon representation of the secondary structure of wild-type and mutant Trxs. The orientation of the structures is the same as in Figures 1 and 4(a).