Oxidative Medicine and Cellular Longevity

Redox Homeostasis and Cancer


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
06 Sep 2019

Lead Editor

1Indiana University School of Medicine, Indianapolis, USA

2Royal Institute of Technology, Stockholm, Sweden

3The Ohio State University Medical Center, Columbus, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Redox Homeostasis and Cancer

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Under physiological conditions, a balance between oxidants and antioxidants exists. Reactive oxygen species (ROS) are continuously generated by aerobic cells and eliminated through scavenging systems to maintain redox homeostasis. Disruption of redox homeostasis results in oxidative stress and altered ROS signaling. Higher ROS levels can lead to DNA mutation and genomic instability which can play causal role in cancer development and progression. These mutations, coupled with distorted redox signaling pathways, orchestrate pathologic events inside cancer cells resulting in resistance to stress and death signals, aberrant proliferation, and inefficient repair mechanisms.

Cancer cells are energy hungry, owing to their high rate of proliferation. However, due to impaired TCA cycle and poor blood perfusion, cancer cells switch towards a glycolytic pathway for energy generation termed as ‘Warburg effect’. Such pathways lead to higher oxidative environment. The oxidative environment is also enhanced by tumor-infiltrating macrophages and neutrophils. Thus cancer cells are used to a high ROS environment. This redox imbalance allows protumorigenic cell signaling.

In this issue, we explore the relation between ROS and cancer. Although ROS sustain tumorigenesis and cancer progression, these can also be efficient therapeutic tools to fight cancer. Oxidative stress based therapies, like radiotherapy, chemotherapeutic agents, and photodynamic theory, increase ROS levels in the tumor niche, taking advantage of the cytotoxic face of ROS for killing tumor cells through a sudden, localized, and intense oxidative burst. Clinical efficacy of anticancer therapies is often subdued by multidrug resistance (MDR). Redox therapy, using redox-active drugs or inhibitors of inducible antioxidant defense in the tumor microenvironment, has been reported to be effective against MDR tumors.

In light of these developments, we invite authors to contribute original research articles, as well as review articles, exploring the role of redox and its regulation in cancer.

Potential topics include but are not limited to the following:

  • Reactive oxygen species (ROS) mediated genomic and epigenomic instability
  • Redox signaling as a driving force for epigenetic modifications
  • Transcriptional regulation of Warburg effect
  • Redox and metabolic circuits in cancer
  • Role of tumor infiltrating macrophages and neutrophils in the cancer redox environment
  • Redox signaling for overcoming multidrug resistance in cancer chemotherapy
  • Dietary antioxidants and cancer prognosis
  • Role of redox in cancer caused by ionizing radiation
  • Oxidative stress induced by conventional anticancer therapy using ionizing radiation
  • Role of redox associated noncoding RNAs in the etiology of cancer
  • Oxidative stress and estrogen receptor-associated breast carcinogenesis
  • Mitochondrial targeted compounds towards cancer cells

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3457890
  • - Review Article

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Márcia Fernanda Correia Jardim Paz | Marcus Vinícius Oliveira Barros de Alencar | ... | Ana Amélia de Carvalho Melo Cavalcante
  • Special Issue
  • - Volume 2020
  • - Article ID 2930347
  • - Review Article

Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment

Yan Mei Goh | Stefan S. Antonowicz | ... | George B. Hanna
  • Special Issue
  • - Volume 2019
  • - Article ID 5381692
  • - Review Article

Understanding of ROS-Inducing Strategy in Anticancer Therapy

Su Ji Kim | Hyun Soo Kim | Young Rok Seo
  • Special Issue
  • - Volume 2019
  • - Article ID 3643715
  • - Research Article

The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression

Yu Yang | Erhu Fang | ... | Qiang Tong
  • Special Issue
  • - Volume 2019
  • - Article ID 9290728
  • - Research Article

Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy

Bin Zhao | Jie Luo | ... | Peng Shang
  • Special Issue
  • - Volume 2019
  • - Article ID 8201079
  • - Review Article

Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications

Tiziana Tataranni | Claudia Piccoli
  • Special Issue
  • - Volume 2019
  • - Article ID 2360945
  • - Review Article

Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies

Masoud Akbari | Emrullah Sogutdelen | ... | Alp Sener
  • Special Issue
  • - Volume 2019
  • - Article ID 3461251
  • - Research Article

H-Ferritin Affects Cisplatin-Induced Cytotoxicity in Ovarian Cancer Cells through the Modulation of ROS

Alessandro Salatino | Ilenia Aversa | ... | Francesco Costanzo
  • Special Issue
  • - Volume 2019
  • - Article ID 4568964
  • - Review Article

Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling

Elena Butturini | Alessandra Carcereri de Prati | ... | Sofia Mariotto
  • Special Issue
  • - Volume 2019
  • - Article ID 8127362
  • - Review Article

Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis

Dehai Xian | Rui Lai | ... | Jianqiao Zhong
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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