Many natural products possess the ability to protect cells from oxidative stress and death. Consequently they are valuable for treating oxidative stress-related diseases. The overproduction of reactive oxygen species (ROS), oxidative stress, and inflammatory responses are involved in the pathogenesis of numerous human chronic diseases including cancer. Natural compounds are recognized for their healing properties from ancient time. Despite the bioactivity of natural compounds, its development towards clinics is usually hampered due to the unknown metabolism in humans and unidentified molecular mechanisms involved. Therefore, advanced and innovative studies of natural products should be performed to support their application in the prevention and treatment of oxidative stress-related human diseases and for the development of novel anticancer nature-inspired drugs.

The aim of this special issue is to emphasize the medicinal value of different natural products and their derivatives, particularly those which can be further developed for the prevention and treatment of oxidative-stress related diseases such as cancer. The articles within this special issue should provide information about efficacy and safety of different natural products and their potential to be developed as new anticancer drugs. Areas of interest include the interaction of natural products and/or their metabolites with intracellular targets associated with the pathology of oxidative stress-related diseases such as cancer.

Original research and review articles which describe the current state of the art of the topics of interest are welcome.

Potential topics include but are not limited to the following:

• Natural products-induced molecular responses to mechanisms related to cancer: gene mutations, oxidative stress, cell metabolism, and hampered immunity
• The role of natural products in the prevention and treatment of diseases related to oxidative stress and cancer (in vitro and in vivo studies)
• Clinical studies to evaluate the impact of food supplements or nutraceuticals in oxidative stress and cancer biomarkers
• Epidemiological studies evaluating preventive effects of natural products against development of cancer