Oxidative Medicine and Cellular Longevity

MicroRNA Regulation of Oxidative Stress


Status
Published

1US Army Institute of Surgical Research, San Antonio, USA

2Ohio State University Wexner Medical Center, Columbus, USA

3University of Texas at San Antonio, San Antonio, USA


MicroRNA Regulation of Oxidative Stress

Description

Reactive oxygen species (ROS) such as peroxides, superoxide, hydroxyl radicals, and singlet oxygen species and reactive nitrogen species (RNS) such as nitroxyl anion, nitrosonium cation, higher oxides of nitrogen, S-nitrosothiols, and dinitrosyl iron complexes at physiological levels are important signaling molecules maintaining cellular homeostasis. Redox imbalance is characteristic in the pathogenesis and pathophysiology of many diseases. Excessive ROS/RNS is either a cause or an important mediator of a number of pathologies. It results in oxidative damage to various biological macromolecules including DNA, lipids, and proteins, thereby altering several signaling pathways that ultimately promote cellular damage and death. Recent advances in the field suggest that a number of pathophysiological changes result from changes in the gene expression.

MicroRNAs, discovered in early 1990s, are a family of small noncoding RNA molecules which regulate gene expression. Over the last decade, microRNAs have been implicated in a broad spectrum of human diseases. It is therefore critical to advance the knowledge of this relationship between oxidative damage and microRNA regulation in diseases to better understand the molecular mechanisms and develop novel therapies.

We invite researchers to contribute original research articles as well as review articles that will enhance the ongoing efforts to understand the molecular mechanisms that regulate oxidative stress and DNA damage in disease pathophysiology via regulation of gene expression by microRNAs.

Potential topics include but are not limited to the following:

  • MicroRNAs as biomarkers of diseases
  • MicroRNA mediated regulation of cell signaling and function with special reference to oxidative stress at cellular or subcellular levels
  • Involvement of microRNA in oxidative stress induced DNA damage
  • MicroRNAs regulating mitochondrial bioenergetics
  • Dietary supplements/nutraceuticals mediated regulation of microRNAs for reducing oxidative and DNA damage
  • Diagnostic and therapeutic application of microRNA mimics, inhibitors, and target-site blockers in mitigating disease pathology

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2872156
  • - Editorial

MicroRNA Regulation of Oxidative Stress

Jaideep Banerjee | Savita Khanna | Akash Bhattacharya
  • Special Issue
  • - Volume 2017
  • - Article ID 2709053
  • - Research Article

MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1

Wen Li | Yue Yang | ... | Du Feng
  • Special Issue
  • - Volume 2017
  • - Article ID 9308310
  • - Research Article

miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells

Rocco Caggiano | Fabio Cattaneo | ... | Raffaella Faraonio
  • Special Issue
  • - Volume 2017
  • - Article ID 3960197
  • - Research Article

circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis

Xing-Ya Guo | Jian-Neng Chen | ... | Jian-Gao Fan
  • Special Issue
  • - Volume 2017
  • - Article ID 5189138
  • - Research Article

Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma

Yong Wan | Ruixia Cui | ... | Ting Lin
  • Special Issue
  • - Volume 2017
  • - Article ID 5025610
  • - Review Article

Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression

Julie Chao | Youming Guo | ... | Lee Chao
  • Special Issue
  • - Volume 2017
  • - Article ID 6051874
  • - Research Article

miR-Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition

Juhyun Song | So Ra Yoon | Oh Yoen Kim
  • Special Issue
  • - Volume 2017
  • - Article ID 4708516
  • - Research Article

miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1

Yi Fang | Ting Xie | ... | Xiaoqiang Ding
  • Special Issue
  • - Volume 2017
  • - Article ID 7038789
  • - Clinical Study

Actinidia chinensis Planch. Improves the Indices of Antioxidant and Anti-Inflammation Status of Type 2 Diabetes Mellitus by Activating Keap1 and Nrf2 via the Upregulation of MicroRNA-424

Longfeng Sun | Xiaofei Li | ... | Wei Tan
  • Special Issue
  • - Volume 2017
  • - Article ID 9397631
  • - Research Article

NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways

Hua Liu | Jinju Wang | ... | Yi Yang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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