Oxidative Medicine and Cellular Longevity

Mechanisms of Cell Damage in Neurological Diseases and Putative Neuroprotective Strategies


Status
Published

1National Institute of Neurology and Neurosurgery, Mexico City, Mexico

2Universidad de Leon, León, Spain


Mechanisms of Cell Damage in Neurological Diseases and Putative Neuroprotective Strategies

Description

Several mechanisms of cellular damage are involved in the pathophysiology of neurological disorders such as stroke, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, acquired immunodeficiency syndrome- (AIDS-) dementia complex, amyotrophic lateral sclerosis, and hepatic encephalopathy. These mechanisms include excitotoxicity, increases in intracellular Ca2+ levels, overproduction of reactive oxygen and nitrogen species, mitochondrial damage, and inflammation. They result in the death of cerebral tissue through different types of cell death, such as necrosis, apoptosis, and necroptosis. Alterations in cellular energy levels, the redox state, and Ca2+ concentrations reduce the protein folding capacity of the endoplasmic reticulum and lead to the accumulation and aggregation of unfolded proteins, a condition known as endoplasmic reticulum stress. Study of the mechanisms of cellular damage will allow the development of new therapeutic targets for the treatment of these debilitating diseases.

This special issue aims to publish high-quality original articles and review articles relating to the mechanisms involved in the pathophysiology of neurological diseases and possible neuroprotective strategies.

Potential topics include but are not limited to the following:

  • Role of endoplasmic reticulum stress in neurological disorders
  • Role of oxidative stress in neurological disorders
  • Role of inflammation in neurological disorders
  • Role of ion dysfunction in neurological disorders
  • Characterization of pathways that protect against oxidative damage, such as Nrf2 and CREB transcription factors
  • Effect of natural products on oxidative stress in relation to neurological disorders

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9784319
  • - Editorial

Mechanisms of Cell Damage in Neurological Diseases and Putative Neuroprotective Strategies

Perla D. Maldonado | María Elena Chánez-Cárdenas | Arsenio Fernández-López
  • Special Issue
  • - Volume 2018
  • - Article ID 4248526
  • - Research Article

17β-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia

Roshni Thakkar | Ruimin Wang | ... | Darrell W. Brann
  • Special Issue
  • - Volume 2018
  • - Article ID 6501031
  • - Review Article

Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury

Michelle A. Bylicky | Gregory P. Mueller | Regina M. Day
  • Special Issue
  • - Volume 2018
  • - Article ID 2596043
  • - Review Article

Cell Type-Specific Mechanisms in the Pathogenesis of Ischemic Stroke: The Role of Apoptosis Signal-Regulating Kinase 1

So Yeong Cheon | Eun Jung Kim | ... | Bon-Nyeo Koo
  • Special Issue
  • - Volume 2017
  • - Article ID 9245702
  • - Research Article

Vitamin D Receptor Activation Influences NADPH Oxidase (NOX2) Activity and Protects against Neurological Deficits and Apoptosis in a Rat Model of Traumatic Brain Injury

Changmeng Cui | Sixin Song | ... | Pei Jiang
  • Special Issue
  • - Volume 2017
  • - Article ID 7191856
  • - Research Article

Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke

Ziying Wang | Zhuanli Zhou | ... | Fan Yi
  • Special Issue
  • - Volume 2017
  • - Article ID 6297080
  • - Research Article

Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid

Aimee N. Winter | Matthew C. Brenner | ... | Daniel A. Linseman
  • Special Issue
  • - Volume 2017
  • - Article ID 8640284
  • - Research Article

Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury

Lei Xie | Sifei Yu | ... | Yu Liang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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