Oxidative Medicine and Cellular Longevity

Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment


Publishing date
25 Aug 2017
Status
Published
Submission deadline
07 Apr 2017

Lead Editor

1University of North Carolina, Greensboro, USA

2University of Utah, Salt Lake City, USA

3Zhejiang University, Hangzhou, China

4University of Arkansas, Fayetteville, USA


Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment

Description

Many studies suggest that reactive oxygen species (ROS) is a mediator of inflammation. Indeed, overproduction of ROS and its association with the oxidative stress and inflammatory responses play a crucial role in the pathogenesis of various human chronic diseases including diabetes, cardiovascular diseases, obesity, cancer, infection diseases, and neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Enhanced ROS production and its consequent oxidative stress can cause oxidative damage of the cellular macromolecules including lipids, proteins, and DNA as well as the modulation of anti-inflammatory and antioxidative systems. Moreover, oxidative stress has been shown to induce the expression of numerous genes involved in inflammatory responses and cellular defense mechanisms including nuclear factor-kappa B (NF-κB), nuclear factor-erythroid 2-related factor 2 (Nrf2), antioxidant responsive elements (ARE), and various anti-inflammatory and antioxidative genes.

Recent studies show that certain natural compounds and/or their derived small molecules may protect cells from oxidative stress as antioxidants, thus ameliorating various oxidative stress related diseases, such as diabetes, cardiovascular diseases, obesity, cancer, and neurodegenerative diseases, infection diseases, and various inflammation conditions. However, a large number of natural products yet remain underutilized and unexploited and their underlying mechanisms are unclear. Thus, understanding of precise mechanisms of actions of natural products would shed further light into the application of these compounds on prevention and treatment of oxidative stress related diseases.

In this special issue, we invite investigators to contribute recent original research articles both in experimental and in clinical data as well as review articles, which will better understand the precise effects of natural compounds in various disease models both in vitro and in vivo and further explore the cellular and molecular mechanisms underlying their actions.

Potential topics include but are not limited to the following:

  • Human, animal, or in vitro studies in relation to oxidative stress and inflammation: extraction, purification of natural compounds from functional foods, medicinal plants, and herbs and their application on oxidative stress related diseases
  • Molecular mechanisms of antioxidative and anti-inflammatory effects of natural compounds in diabetes, cardiovascular diseases, obesity, cancer, and neurodegenerative diseases, infection diseases, and various inflammation conditions: ROS-mediated signaling and redox modulation
  • Molecular mechanisms of antioxidative and anti-inflammatory effects of natural compounds against ROS-induced oxidative damage and toxicity
  • Isolation, chemical characterization, and pharmacological evaluation of novel natural compounds from functional foods, medicinal plants, and herbs in relation to oxidative stress and inflammation
  • Approaches and the safety assessment of natural ingredients and extracts

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 6576093
  • - Editorial

Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment

Zhenquan Jia | Pon Velayutham Anandh Babu | ... | Xiaolun Sun
  • Special Issue
  • - Volume 2017
  • - Article ID 9821543
  • - Research Article

Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation

Zhilin Qi | Yao Zhang | ... | Qiang Li
  • Special Issue
  • - Volume 2017
  • - Article ID 1956104
  • - Research Article

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice

Fumiya Harada | Tetsuro Morikawa | ... | Nobuyoshi Kitaichi
  • Special Issue
  • - Volume 2017
  • - Article ID 7601592
  • - Research Article

Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation

Kaiping Wang | Jun Wu | ... | Yu Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 9260701
  • - Research Article

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

Katarzyna Goszcz | Sherine J. Deakin | ... | Ian L. Megson
  • Special Issue
  • - Volume 2017
  • - Article ID 9848594
  • - Research Article

Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach

Qian Zhang | Xiaowei Fu | ... | Lingyi Kong
  • Special Issue
  • - Volume 2017
  • - Article ID 1594963
  • - Research Article

Mulberry Fruit Extract Affords Protection against Ethyl Carbamate-Induced Cytotoxicity and Oxidative Stress

Wei Chen | Yuting Li | ... | Vemana Gowd
  • Special Issue
  • - Volume 2017
  • - Article ID 6965739
  • - Research Article

Hongjingtian Injection Attenuates Myocardial Oxidative Damage via Promoting Autophagy and Inhibiting Apoptosis

Shujing Zhang | Ling Zhang | ... | Xiaoping Zhao
  • Special Issue
  • - Volume 2017
  • - Article ID 2190897
  • - Research Article

Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats

WeiHeng Wang | Xiaodong Huang | ... | Xiaojian Ye
  • Special Issue
  • - Volume 2017
  • - Article ID 3159358
  • - Research Article

Antifatigue Effect of Luteolin-6-C-Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

Fang-fang Duan | Ying Guo | ... | Ke Yuan
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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