Oxidative Medicine and Cellular Longevity

From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells


Status
Published

Lead Editor

1University of Leuven, Leuven, Belgium

2University of Minho, Braga, Portugal

3Stockholm University, Stockholm, Sweden


From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells

Description

Regulated cell death (RCD) encompasses different active forms of cell death ranging from apoptosis to necrosis or autophagy that are governed by distinct and highly sophisticated molecular pathways. An event intimately associated with RCD and RCD associated pathologies, such as neurodegenerative or proliferative disorders, is oxidative stress. A better understanding of how a cell responds to RCD-inducing oxidative stress will undoubtely uncover novel adaptive stress strategies, thereby providing more insights towards pro-RCD therapies. To uncover the complex network of the different and often interwoven RCD pathways and their association with oxidative stress, as well as for drug discovery purposes, the budding yeast Saccharomyces cerevisiae is successfully used as a model organism. In addition, the analysis of cell death routes solely present/induced in yeast and other fungi might point to novel therapeutic strategies to combat fungal infections.

We invite investigators to contribute with original research articles as well as reviews that address the molecular mechanisms underlying the induction and execution of RCD upon diverse types of stress and their association with oxidative stress, in natural scenarios such as aging or disease, or after challenge with external toxins. Besides that, analysis of adaptive stress strategies or tolerance mechanisms elicited by different organisms under RCD stress or oxidative stress in general will be of interest. Focus can be on mammalian cell setups as well as on yeast and other eukaryotes. In addition, translational aspects focusing, for instance, on the discovery of novel therapies for RCD-based pathologies or to fight fungal infections, combination therapy targeting RCD tolerance mechanisms, and/or the in vivo efficacy of mono- or combination therapy in animal disease models will be highly relevant.

Potential topics include but are not limited to the following:

  • The identification of novel RCD executors
  • The identification of adaptive responses to RCD or oxidative stress in diverse eukaryotic cells
  • The interplay between different forms of RCD and how this connects to aging and disease
  • Signals directing cells towards specific fates (survival or death), including the autophagy/apoptosis checkpoint, its regulation, and function in relation to disease
  • RCD-related disease models based on human cellular models as well as on different yeast species such as Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Candida albicans
  • Novel drugs/technologies to manipulate RCD associated with oxidative stress in a therapeutic context, including RCD-inducing antifungals and anticancer drugs, with a focus on tackling drug resistance

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2480462
  • - Editorial

From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells

Sabrina Büttner | Paula Ludovico | Karin Thevissen
  • Special Issue
  • - Volume 2018
  • - Article ID 4701275
  • - Review Article

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

Katrina F. Cooper
  • Special Issue
  • - Volume 2018
  • - Article ID 2138502
  • - Review Article

Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms

Mathias Cobbaut | Johan Van Lint
  • Special Issue
  • - Volume 2018
  • - Article ID 5473817
  • - Review Article

Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics

Michael R. Yeaman | Sabrina Büttner | Karin Thevissen
  • Special Issue
  • - Volume 2018
  • - Article ID 1324739
  • - Research Article

An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention

Abhishek A. Kulkarni | Abass M. Conteh | ... | Ryan M. Anderson
  • Special Issue
  • - Volume 2018
  • - Article ID 2389523
  • - Review Article

Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies

Pierpaola Davalli | Gaetano Marverti | ... | Domenico D’Arca
  • Special Issue
  • - Volume 2018
  • - Article ID 5801209
  • - Review Article

Reactive Oxygen Species-Mediated Tumor Microenvironment Transformation: The Mechanism of Radioresistant Gastric Cancer

Huifeng Gu | Tianhe Huang | ... | Yongchang Wei
  • Special Issue
  • - Volume 2018
  • - Article ID 4950591
  • - Review Article

Long Noncoding RNAs in Yeast Cells and Differentiated Subpopulations of Yeast Colonies and Biofilms

Derek Wilkinson | Libuše Váchová | ... | Zdena Palková
  • Special Issue
  • - Volume 2018
  • - Article ID 1052413
  • - Research Article

Changes of KEAP1/NRF2 and IKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types

Svetlana V. Kostyuk | Lev N. Porokhovnik | ... | Nataliya N. Veiko
  • Special Issue
  • - Volume 2018
  • - Article ID 1898421
  • - Research Article

Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains

Renata Zadrag-Tecza | Magdalena Kwolek-Mirek | ... | Adrianna Skoneczna
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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