Table of Contents Author Guidelines Submit a Manuscript
Parkinson’s Disease
Volume 2011, Article ID 438370, 10 pages
http://dx.doi.org/10.4061/2011/438370
Research Article

Protective Role of rAAV-NDI1, Serotype 5, in an Acute MPTP Mouse Parkinson's Model

1Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM256, La Jolla, CA 92037, USA
2Department of Animal Resources, College of Life & Environmental Science, Daegu University, Jillyang, Gyeongsan, Gyeongbuk 712-714, Republic of Korea

Received 15 September 2010; Accepted 22 October 2010

Academic Editor: Yuzuru Imai

Copyright © 2011 Jennifer Barber-Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. M. Abou-Sleiman, M. M. K. Muqit, and N. W. Wood, “Expanding insights of mitochondrial dysfunction in Parkinson's disease,” Nature Reviews Neuroscience, vol. 7, no. 3, pp. 207–219, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. M. R. Cookson, “The biochemistry of Parkinson's disease,” Annual Review of Biochemistry, vol. 74, pp. 29–52, 2005. View at Google Scholar · View at Scopus
  3. W. Dauer and S. Przedborski, “Parkinson's disease: mechanisms and models,” Neuron, vol. 39, no. 6, pp. 889–909, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. H. V. Schapira, “Etiology of Parkinson's disease,” Neurology, vol. 66, no. 10, supplement 4, pp. S10–S15, 2006. View at Google Scholar · View at Scopus
  5. T. R. Flotte, “Gene therapy: the first two decades and the current state-of-the-art,” Journal of Cellular Physiology, vol. 213, no. 2, pp. 301–305, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. S. G. Speciale, “MPTP: insights into parkinsonian neurodegeneration,” Neurotoxicology and Teratology, vol. 24, no. 5, pp. 607–620, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Barber-Singh, B. B. Seo, E. Nakamaru-Ogiso, Y. S. Lau, A. Matsuno-Yagi, and T. Yagi, “Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of parkinson disorder,” Rejuvenation Research, vol. 12, no. 4, pp. 259–267, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Kurosaki, Y. Muramatsu, H. Kato, and T. Araki, “Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease,” Pharmacology Biochemistry and Behavior, vol. 78, no. 1, pp. 143–153, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Sedelis, R. K. W. Schwarting, and J. P. Huston, “Behavioral phenotyping of the MPTP mouse model of Parkinson's disease,” Behavioural Brain Research, vol. 125, no. 1-2, pp. 109–125, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Burger, K. Nash, and R. J. Mandel, “Recombinant adeno-associated viral vectors in the nervous system,” Human Gene Therapy, vol. 16, no. 7, pp. 781–791, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Wu, A. Asokan, and R. J. Samulski, “Adeno-associated virus serotypes: vector toolkit for human gene therapy,” Molecular Therapy, vol. 14, no. 3, pp. 316–327, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Burton, J. C. Glorioso, and D. J. Fink, “Gene therapy progress and prospects: Parkinson's disease,” Gene Therapy, vol. 10, no. 20, pp. 1721–1727, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. During and P. Leone, “Targets for gene therapy of Parkinson's disease: growth factors, signal transduction, and promoters,” Experimental Neurology, vol. 144, no. 1, pp. 74–81, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. M. G. Kaplitt, A. Feigin, C. Tang et al., “Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial,” Lancet, vol. 369, no. 9579, pp. 2097–2105, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. B. B. Seo, T. Kitajima-Ihara, E. K. L. Chan, I. E. Scheffler, A. Matsuno-Yagi, and T. Yagi, “Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 16, pp. 9167–9171, 1998. View at Google Scholar · View at Scopus
  16. T. Yagi, B. B. Seo, E. Nakamaru-Ogiso et al., “Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?” Rejuvenation Research, vol. 9, no. 2, pp. 191–197, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Marella, B. B. Seo, T. Yagi, and A. Matsuno-Yagi, “Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy,” Journal of Bioenergetics and Biomembranes, vol. 41, no. 6, pp. 493–497, 2009. View at Google Scholar
  18. B. B. Seo, E. Nakamaru-Ogiso, P. Cruz, T. R. Flotte, T. Yagi, and A. Matsuno-Yagi, “Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: a potential therapy for complex I deficiencies,” Human Gene Therapy, vol. 15, no. 9, pp. 887–895, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. B. B. Seo, E. Nakamaru-Ogiso, T. R. Flotte, A. Matsuno-Yagi, and T. Yagi, “In vivo complementation of complex I by the yeast Ndi1 enzyme: possible application for treatment of Parkinson disease,” Journal of Biological Chemistry, vol. 281, no. 20, pp. 14250–14255, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Yagi, B. B. Seo, E. Nakamaru-Ogiso et al., “Possibility of transkingdom gene therapy for complex I diseases,” Biochimica et Biophysica Acta, vol. 1757, no. 5-6, pp. 708–714, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. C. V. Borlongan and P. R. Sanberg, “Elevated body swing test: a new behavioral parameter for rats with 6- hydroxydopamine-induced hemiparkinsonism,” Journal of Neuroscience, vol. 15, no. 7, part 1, pp. 5372–5378, 1995. View at Google Scholar · View at Scopus
  22. R. Iancu, P. Mohapel, P. Brundin, and G. Paul, “Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice,” Behavioural Brain Research, vol. 162, no. 1, pp. 1–10, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Marella, B. B. Seo, E. Nakamaru-Ogiso, J. T. Greenamyre, A. Matsuno-Yagi, and T. Yagi, “Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease,” PLos One, vol. 3, no. 1, Article ID e1433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Marella, B. B. Seo, B. B. Thomas, A.. Matsuno-Yagi, and T. Yagi, “Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model,” Plos One, vol. 5, no. 7, Article ID e11472, 2010. View at Google Scholar · View at Scopus
  25. M. D. Abràmoff, P. J. Magalhães, and S. J. Ram, “Image processing with imageJ,” Biophotonics International, vol. 11, no. 7, pp. 36–41, 2004. View at Google Scholar · View at Scopus
  26. M. E. Emborg, M. Carbon, J. E. Holden et al., “Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism,” Journal of Cerebral Blood Flow and Metabolism, vol. 27, no. 3, pp. 501–509, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. D. N. Abrous, J. J. Rodriguez, M.-F. Montaron, C. Aurousseau, M. Le Moal, and P. Barneoud, “Behavioural recovery after unilateral lesion of the dopaminergic mesotelencephalic pathway: effect of repeated testing,” Neuroscience, vol. 84, no. 1, pp. 213–221, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. C. J. Pycock, “Turning behaviour in animals,” Neuroscience, vol. 5, no. 3, pp. 461–514, 1980. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Henderson, S. Watson, G. M. Halliday, T. Heinemann, and M. Gerlach, “Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat,” Behavioural Brain Research, vol. 139, no. 1-2, pp. 105–113, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Bezard, S. Dovero, B. Bioulac, and C. E. Gross, “Kinetics of nigral degeneration in a chronic model of MPTP-treated mice,” Neuroscience Letters, vol. 234, no. 1, pp. 47–50, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. B. B. Seo, E. Nakamaru-Ogiso, T. R. Flotte, T. Yagi, and A. Matsuno-Yagi, “A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition,” Molecular Therapy, vol. 6, no. 3, pp. 336–341, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. W. Jakowec, K. Nixon, E. Hogg, T. McNeill, and G. M. Petzinger, “Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway,” Journal of Neuroscience Research, vol. 76, no. 4, pp. 539–550, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Przedborski and M. Vila, “The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease,” Annals of the New York Academy of Sciences, vol. 991, pp. 189–198, 2003. View at Google Scholar · View at Scopus
  34. M. Gerlach, P. Riederer, H. Przuntek, and M. B. H. Youdim, “MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease,” European Journal of Pharmacology, vol. 208, no. 4, pp. 273–286, 1991. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Przedborski, K. Tieu, C. Perier, and M. Vila, “MPTP as a mitochondrial neurotoxic model of Parkinson's disease,” Journal of Bioenergetics and Biomembranes, vol. 36, no. 4, pp. 375–379, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. B. B. Seo, M. Marella, T. Yagi, and A. Matsuno-Yagi, “The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I,” FEBS Letters, vol. 580, no. 26, pp. 6105–6108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Marella, B. B. Seo, A. Matsuno-Yagi, and T. Yagi, “Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line,” Journal of Biological Chemistry, vol. 282, no. 33, pp. 24146–24156, 2007. View at Publisher · View at Google Scholar · View at Scopus