Table of Contents Author Guidelines Submit a Manuscript
Parkinson’s Disease
Volume 2011, Article ID 716859, 11 pages
http://dx.doi.org/10.4061/2011/716859
Review Article

The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease

1Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
2Experimental and Clinical Neuroscience (NiCE-CIBERNED), Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Murcia, Spain
3St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW 2010, Australia

Received 1 December 2010; Accepted 31 January 2011

Academic Editor: Heinz Reichmann

Copyright © 2011 Anna Zinger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [38 citations]

The following is the list of published articles that have cited the current article.

  • Rani K. Powers, Kelly D. Sullivan, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Angelo D’Alessandro, James C. Costello, and Joaquin M. Espinosa. View at Publisher · View at Google Scholar
  • Karlijn J. Doorn, Paul J. Lucassen, Hendrikus W. Boddeke, Marloes Prins, Henk W. Berendse, Benjamin Drukarch, and Anne-Marie van Dam, “Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease,” Progress in Neurobiology, vol. 98, no. 2, pp. 222–238, 2012. View at Publisher · View at Google Scholar
  • Gilles J. Guillemin, “Quinolinic acid, the inescapable neurotoxin,” Febs Journal, vol. 279, no. 8, pp. 1356–1365, 2012. View at Publisher · View at Google Scholar
  • Lin Tan, Jin-Tai Yu, and Lan Tan, “The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations,” Journal Of The Neurological Sciences, vol. 323, no. 1-2, pp. 1–8, 2012. View at Publisher · View at Google Scholar
  • Allen T. Hopper, Brian M. Campbell, Henry Kao, Sean A. Pintchovski, and Roland G.W. Staal, “Recent Developments in Targeting Neuroinflammation in Disease,” Annual Reports in Medicinal Chemistry, vol. 47, pp. 37–53, 2012. View at Publisher · View at Google Scholar
  • Peter A. LeWitt, Jia Li, Mei Lu, Thomas G. Beach, Charles H. Adler, and Lining Guo, “3-Hydroxykynurenine and Other Parkinson's Disease Biomarkers Discovered by Metabolomic Analysis,” Movement Disorders, vol. 28, no. 12, pp. 1653–1660, 2013. View at Publisher · View at Google Scholar
  • Andreas Meinitzer, Andreas Tomaschitz, Stefan Pilz, Manfred Truber, Gabriele Zechner, Martin Gaksch, Barbara Prietl, Genies Treiber, Michaela Schwarz, and Andreas Baranyi, “Development of a liquid chromatography-mass spectrometry method for the determination of the neurotoxic quinolinic acid in human serum,” Clinica Chimica Acta, vol. 436, pp. 268–272, 2014. View at Publisher · View at Google Scholar
  • Lay Khoon Too, James A. McQuillan, Helen J. Ball, Masaaki Kanai, Toshikazu Nakamura, Hiroshi Funakoshi, Iain S. McGregor, and Nicholas H. Hunt, “The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis,” Behavioural Brain Research, vol. 270, pp. 179–195, 2014. View at Publisher · View at Google Scholar
  • Robert S. Phillips, “Structure and mechanism of kynureninase,” Archives of Biochemistry and Biophysics, vol. 544, pp. 69–74, 2014. View at Publisher · View at Google Scholar
  • Jonas I. Addae, and Trevor W. Stonevol. 2, pp. 1543–1565, 2014. View at Publisher · View at Google Scholar
  • Kouji Fukuyama, Shunske Tanahashi, Masamitsu Hoshikawa, Rika Shinagawa, and Motohiro Okada, “Zonisamide regulates basal ganglia transmission via astroglial kynurenine pathway,” Neuropharmacology, vol. 76, pp. 137–145, 2014. View at Publisher · View at Google Scholar
  • Brian M. Campbell, Erik Charych, Anna W. Lee, and Thomas Möller, “Kynurenines in CNS disease: Regulation by inflammatory cytokines,” Frontiers in Neuroscience, no. 8, 2014. View at Publisher · View at Google Scholar
  • Alla B. Salmina, Yulia K. Komleva, Olga L. Lopatina, Natalia V. Kuvacheva, Yana V. Gorina, Yulia A. Panina, Yulia A. Uspenskaya, Marina M. Petrova, Irina V. Demko, Anna S. Zamay, and Natalia A. Malinovskaya, “Astroglial control of neuroinflammation: TLR3-mediated dsRNA-sensing pathways are in the focus,” Reviews In The Neurosciences, vol. 26, no. 2, pp. 143–159, 2015. View at Publisher · View at Google Scholar
  • Maria D. Chikina, Christophe P. Gerald, Xianting Li, Yongchao Ge, Hanna Pincas, Venugopalan D. Nair, Aaron K. Wong, Arjun Krishnan, Olga G. Troyanskaya, Deborah Raymond, Rachel Saunders-Pullman, Susan B. Bressman, Zhenyu Yue, and Stuart C. Sealfon, “Low-Variance RNAs Identify Parkinson's Disease Molecular Signature in Blood,” Movement Disorders, 2015. View at Publisher · View at Google Scholar
  • Katherine O'Farrell, and Andrew Harkin, “Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders,” Neuropharmacology, 2015. View at Publisher · View at Google Scholar
  • Gerwyn Morris, Michael Berk, Piotr Galecki, Ken Walder, and Michael Maes, “The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases,” Molecular Neurobiology, 2015. View at Publisher · View at Google Scholar
  • Zhiming Cui, Li Zhou, Chun Liu, Guanghui Zhu, Xinmin Wu, Yaohua Yan, Xiaopeng Xia, Zhiyun Ben, Yan Song, Ying Zhou, Haiyan Zhang, and Dongmei Zhang, “The Role of Homer1b/c in Neuronal Apoptosis Following LPS-Induced Neuroinflammation,” Neurochemical Research, vol. 40, no. 1, pp. 204–215, 2015. View at Publisher · View at Google Scholar
  • Gilles J. Guillemin, and Chai K. Limpp. 419–425, 2015. View at Publisher · View at Google Scholar
  • Jonathan Peter Little, Andis Klegeris, and Lindsay Joy Spielman, “Physical activity and exercise attenuate neuroinflammation in neurological diseases,” Brain Research Bulletin, vol. 125, pp. 19–29, 2016. View at Publisher · View at Google Scholar
  • G. Świderski, H. Lewandowska, R. Świsłocka, S. Wojtulewski, L. Siergiejczyk, A.Z. Wilczewska, and I. Misztalewska, “Spectroscopic (IR, Raman, NMR), thermal and theoretical (DFT) study of alkali metal dipicolinates (2,6) and quinolinates (2,3),” Arabian Journal of Chemistry, 2016. View at Publisher · View at Google Scholar
  • Alireza Nematollahi, Guanchen Sun, Gayan Jayawickrama, Jane Hanrahan, and W. Church, “Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders,” Molecules, vol. 21, no. 7, pp. 856, 2016. View at Publisher · View at Google Scholar
  • Gwenn A. Garden, and Brian M. Campbell, “Glial biomarkers in human central nervous system disease,” Glia, 2016. View at Publisher · View at Google Scholar
  • Chai K. Lim, Francisco J. Fernández-Gomez, Nady Braidy, Cristina Estrada, Cristina Costa, Silvia Costa, Alban Bessede, Emiliano Fernandez-Villalba, Anna Zinger, Maria Trinidad Herrero, and Gilles J. Guillemin, “Involvement of the kynurenine pathway in the pathogenesis of Parkinson’s disease,” Progress in Neurobiology, 2016. View at Publisher · View at Google Scholar
  • Josien de Bie, Jade Guest, Gilles J. Guillemin, and Ross Grant, “Central kynurenine pathway shift with age in women,” Journal Of Neurochemistry, vol. 136, no. 5, pp. 995–1003, 2016. View at Publisher · View at Google Scholar
  • Erika M Palmieri, Alessio Menga, Aurore Lebrun, Douglas C Hooper, D. Allan Butterfield, Massimiliano Mazzone, and Alessandra Castegna, “Blockade of glutamine synthetase enhances inflammatory response in microglial cells,” Antioxidants & Redox Signaling, 2016. View at Publisher · View at Google Scholar
  • Joerg C. Schefold, Nora Fritschi, Stephan von Haehling, Tim Schroeder, Gerhard Fusch, Aldin Bahonjic, Wolfram Doehner, Rene Pschowski, and Christian Storm, “Influence of core body temperature on Tryptophan metabolism, kynurenines, and estimated IDO activity in critically ill patients receiving target temperature management following cardiac arrest,” Resuscitation, vol. 107, pp. 107–114, 2016. View at Publisher · View at Google Scholar
  • Kong M. Li, Ghassan J. Maghzal, Roland Stocker, Iain S. McGregor, Lay Khoon Too, Cacang Suarna, and Nicholas H. Hunt, “Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function,” Behavioural Brain Research, vol. 312, pp. 102–117, 2016. View at Publisher · View at Google Scholar
  • Hui Zuo, Per M. Ueland, Arve Ulvik, Simone J. P. M. Eussen, Stein E. Vollset, Ottar Nygård, Øivind Midttun, Despoina Theofylaktopoulou, Klaus Meyer, and Grethe S. Tell, “Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality,” American Journal of Epidemiology, pp. kwv242, 2016. View at Publisher · View at Google Scholar
  • Eyad T. Marashly, and Saeed A. Bohlega, “Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine,” Frontiers in Neurology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Peter P. Sordillo, Laura A. Sordillo, and Lawrence Helson, “The kynurenine pathway: A primary resistance mechanism in patients with glioblastoma,” Anticancer Research, vol. 37, no. 5, pp. 2159–2171, 2017. View at Publisher · View at Google Scholar
  • Chaitanya R. Joshi, Vinod Labhasetwar, and Anuja Ghorpade, “Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery,” Journal of Neuroimmune Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Keerthi Thirtamara-Rajamani, Peipei Li, Martha L Escobar Galvis, Viviane Labrie, Patrik Brundin, and Lena Brundin, “Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?,” Journal of Parkinson's disease, vol. 7, no. 4, pp. 577–587, 2017. View at Publisher · View at Google Scholar
  • Andrew Harkin, Kelly A. Allers, Sina Pleiner, Leonardo Tozzi, Erik O'Hanlon, Darren Roddy, Kelly Doolin, Veronica O'Keane, Andre Liesener, Chloe Farrell, and Thomas Frodl, “Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes,” Psychoneuroendocrinology, vol. 95, pp. 8–17, 2018. View at Publisher · View at Google Scholar
  • Mona Dehhaghi, Vanessa Tan, Benjamin Heng, Nady Braidy, Fatemeh Mohammadipanah, and Gilles J. Guillemin, “Neuroprotective Effect of Myxobacterial Extracts on Quinolinic Acid-Induced Toxicity in Primary Human Neurons,” Neurotoxicity Research, 2018. View at Publisher · View at Google Scholar
  • Li Bo, Tan Guojun, and Guo Li, “An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Emily L Gill, Jeremy P Koelmel, Richard A Yost, Michael S Okun, Vinata Vedam-Mai, and Timothy J. Garrett, “Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s disease: Current Progress and Future Perspectives,” Analytical Chemistry, 2018. View at Publisher · View at Google Scholar
  • Andrea Capucciati, Monica Galliano, Luigi Bubacco, Luigi Zecca, Luigi Casella, Enrico Monzani, and Stefania Nicolis, “Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases,” ACS Chemical Neuroscience, 2019. View at Publisher · View at Google Scholar
  • Imre Dékány, Edit Csapó, Ditta Ungor, and Krisztián Horváth, “Red-emitting gold nanoclusters for rapid fluorescence sensing of tryptophan metabolites,” Sensors and Actuators, B: Chemical, vol. 288, pp. 728–733, 2019. View at Publisher · View at Google Scholar