Review Article

Systematic Review and Critical Analysis of Cost Studies Associated with Parkinson’s Disease

Table 2

Main study designs on costs.

ApproachesDescriptionAdvantagesDisadvantages

PrevalenceFrequency measure
It evaluates all existing cases in a given period
Ample results
Specific policy planning
Fast study and recommended for chronic diseases
Considered weak at estimating the risk of developing disease
IncidenceFrequency measure
Assesses the number of new cases in a given period
Implementation of measures to reduce new cases
It is used more for acute diseases, since it estimates the risk of developing the disease
Not recommended for chronic diseases
Top-downIt measures the proportion of a disease attributed to several risk factors. It involves a study directed from total to lower levelsWhen the scope of study is well understoodMore comprehensive, it hampers the study on the details of the disease
Bottom-upRelated to the unit costs of inputs used. It involves the study directed from individual levels to the total.More detailedRisk of double counting
ProspectiveTemporal study, performed during disease. Probes the effect through the causeUsed in chronic diseasesTime-consuming and expensive
RetrospectiveTemporal study performed with preexisting data.
Probes the cause through the effect
Quick and cheaperRisk of memory bias
EconometricComparison of groupsMinor amount of data required
Cost difference between the two populations
Long study, requiring that the control group be paired to the study group
Markov modelsStochastic process
Used in prospective studies. Patients stratified in stages of disease
Dynamic model aiming at studying the transition from one stage to another, evaluating the costs of each stepTransition of stages is independent, without considering the previous one