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Parkinson’s Disease
Volume 2017, Article ID 9641392, 16 pages
Review Article

Meta-Analysis of the Relationship between Deep Brain Stimulation in Patients with Parkinson’s Disease and Performance in Evaluation Tests for Executive Brain Functions

1Department of Psychology, Pontificia Universidad Javeriana, Bogotá, Colombia
2Department of Brain Repair and Rehabilitation, University College London, London, UK

Correspondence should be addressed to C. A. Acevedo-Triana; oc.ude.anairevaj@odeveca.rasec

Received 25 August 2016; Accepted 11 October 2016; Published 8 February 2017

Academic Editor: Rajka M. Liscic

Copyright © 2017 A. M. Martínez-Martínez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Parkinson’s disease (PD) is a neurodegenerative condition, which compromises the motor functions and causes the alteration of some executive brain functions. The presence of changes in cognitive symptoms in PD could be due to the procedure of deep brain stimulation (DBS). We searched in several databases for studies that compared performance in executive function tests before and after the DBS procedure in PE and then performed a meta-analysis. After the initial search, there were 15 articles that specifically evaluated the functions of verbal fluency, working memory, cognitive flexibility, abstract thinking, and inhibition. It was found that there were differences in the evaluation of the cognitive functions in terms of the protocols, which generated heterogeneity in the results of the meta-analysis. Likewise, a tendency to diminish functions like verbal fluency and inhibition was found, being this consistent with similar studies. In the other functions evaluated, no difference was found between pre- and postsurgery scores. Monitoring of this type of function is recommended after the procedure.