Research Article
α-Synuclein E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson’s Disease
Figure 4
Confocal images of the brain of E46K α-synuclein transgenic flies demonstrate degeneration in protocerebral antero-medial (PAM), protocerebral postero-medial (PPM), and protocerebral postero-lateral (PPL) clusters of dopaminergic neurons. (a) GFP/+; Ddc/+, (b) GFP/SNCAWT; Ddc/+, and (c) GFP/SNCAE46K; Ddc/+. Scale bar, 50 μm. (d) Cell counting indicates a significant reduction in the number of dopaminergic neurons up on SNCAE46K overexpression, which was prominent for the PPM cluster (; by t-test; n = 15).
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