|
| Statement | Consensus agreement | Consensus disagreement | No consensus |
|
| S26 | TCAs have important side effects in PD patients. | ✓ | | |
| S27 | The best-tolerated SSRI for PD patients is sertraline. | ✓ | | |
| S28 | The dual SNRIs are effective in PD patients with major depression. | ✓ | | |
| S29 | Among TCAs, nortriptyline shows the best safety profile in PD patients. | ✓ | | |
| S30 | SSRIs and SNRIs (dual) worsen motor symptoms of PD. | | | - |
| S31 | Mirtazapine is an effective and well-tolerated antidepressant drug for PD patients. | ✓ | | |
| S32 | Agomelatine, with norepinephrinergic and indirect dopaminergic effects, is not a drug of choice in PD patients. | | | - |
| S33 | The DA and NE reuptake inhibitor bupropion is effective in PD patients. | ✓ | | |
| S34 | Nonergotic DA-receptor agonists (ropinirole, pramipexole, and rotigotine) are effective for treating PD-related depression. | ✓ | | |
| S35 | The glutamatergic modulator tianeptine is effective for depression in PD patients. | ✓ | | |
| S36 | CBT is effective to treat depression in PD patients. | ✓ | | |
| S37 | Trazodone is an effective treatment for depression in PD. | | | - |
| S38 | Combining anti-Parkinsonian MAO-BIs and serotonergic antidepressants is of limited use given the possible occurrence of a serotonin syndrome in PD. | ✓ | | |
| S39 | Tianeptine is a safe antidepressant in depressive PD patients under treatment with anti-Parkinsonian drugs. | ✓ | | |
| S40 | Vortioxetine is a multimodal antidepressant that is well tolerated in PD patients. | ✓ | | |
| S41 | ECT is an advisable therapeutic approach in patients with dementia and depression that show poor response to antidepressants. | ✓ | | |
| S42 | Given their PD-specific efficacy and tolerability, SSRIs are a good treatment option for depression in PD patients. | ✓ | | |
| S43 | Given their PD-specific efficacy and tolerability, dual and multimodal drugs are a good treatment option for depression in PD patients. | ✓ | | |
| S44 | Given its PD-specific efficacy and tolerability, mirtazapine is a good treatment option for depression in PD patients. | ✓ | | |
| S45 | Given its PD-specific efficacy and tolerability, bupropion is a good treatment option for depression in PD patients. | ✓ | | |
| S46 | Given its PD-specific efficacy and tolerability, nortriptyline is a good treatment option for depression in PD patients. | | | - |
| S47 | Given its PD-specific efficacy and tolerability, agomelatine is a good treatment option for depression in PD patients. | | | - |
| S48 | Given its PD-specific efficacy and tolerability, tianeptine is a good treatment option for depression in PD patients. | ✓ | | |
| S49 | Given its PD-specific efficacy and tolerability, trazodone is a good treatment option for depression in PD patients. | | | - |
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