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Pulmonary Medicine
Volume 2012, Article ID 469128, 6 pages
http://dx.doi.org/10.1155/2012/469128
Research Article

Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)

1Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, Spain
2Unidad de Enfermedades Infecciosas, Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, 39011 Santander, Spain

Received 25 September 2012; Revised 16 November 2012; Accepted 18 November 2012

Academic Editor: José R. Lapa e Silva

Copyright © 2012 J.-Gonzalo Ocejo-Vinyals et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, “Global tuberculosis control: surveillance, planning, financing,” WHO Report 2007, World Health Organization, Geneva, Switzerland, (WHO/HTM/TB/2007. 376).
  2. M. Díez, C. Huerta, T. Moreno et al., “Tuberculosis in Spain: epidemiological pattern and clinical practice,” International Journal of Tuberculosis and Lung Disease, vol. 6, no. 4, pp. 295–300, 2002. View at Google Scholar · View at Scopus
  3. M. Pai, S. Kalantri, and K. Dheda, “New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis,” Expert Review of Molecular Diagnostics, vol. 6, no. 3, pp. 413–422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Pai, S. Kalantri, and K. Dheda, “New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance,” Expert Review of Molecular Diagnostics, vol. 6, no. 3, pp. 423–432, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Selvaraj, “Host genetics and tuberculosis susceptibility,” Current Science, vol. 86, no. 1, pp. 115–121, 2004. View at Google Scholar · View at Scopus
  6. E. Schurr, “Is susceptibility to tuberculosis acquired or inherited?” Journal of Internal Medicine, vol. 261, no. 2, pp. 106–111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Bellamy, “Genome-wide approaches to identifying genetic factors in host susceptibility to tuberculosis,” Microbes and Infection, vol. 8, no. 4, pp. 1119–1123, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. D. L. Worthley, P. G. Bardy, and C. G. Mullighan, “Mannose-binding lectin: biology and clinical implications,” Internal Medicine Journal, vol. 35, no. 9, pp. 548–555, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. W. I. Weis, K. Drickamer, and W. A. Hendrickson, “Structure of a C-type mannose-binding protein complexed with an oligosaccharide,” Nature, vol. 360, no. 6400, pp. 127–134, 1992. View at Publisher · View at Google Scholar · View at Scopus
  10. I. P. Fraser, H. Koziel, and R. A. B. Ezekowitz, “The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity,” Seminars in Immunology, vol. 10, no. 5, pp. 363–372, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Thiel, T. Vorup-Jensen, C. M. Stover et al., “A second serine protease associated with mannan-binding lectin that activates complement,” Nature, vol. 386, no. 6624, pp. 506–510, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Neth, D. L. Jack, A. W. Dodds, H. Holzel, N. J. Klein, and M. W. Turner, “Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition,” Infection and Immunity, vol. 68, no. 2, pp. 688–693, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. D. P. Eisen, “Mannose-binding lectin deficiency and respiratory tract infection,” Journal of Innate Immunity, vol. 2, no. 2, pp. 114–122, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Sumiya, M. Super, P. Tabona et al., “Molecular basis of opsonic defect in immunodeficient children,” The Lancet, vol. 337, no. 8757, pp. 1569–1570, 1991. View at Publisher · View at Google Scholar · View at Scopus
  15. H. O. Madsen, P. Garred, S. Thiel et al., “Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein,” Journal of Immunology, vol. 155, no. 6, pp. 3013–3020, 1995. View at Google Scholar · View at Scopus
  16. F. Larsen, H. O. Madsen, R. B. Sim, C. Koch, and P. Garred, “Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein,” The Journal of Biological Chemistry, vol. 279, no. 20, pp. 21302–21311, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Garred, F. Larsen, J. Seyfarth, R. Fujita, and H. O. Madsen, “Mannose-binding lectin and its genetic variants,” Genes and Immunity, vol. 7, no. 2, pp. 85–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. J. L. Casanova and L. Abel, “Human mannose-binding lectin in immunity: friend, foe, or both?” Journal of Experimental Medicine, vol. 199, no. 10, pp. 1295–1299, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Singla, D. Gupta, A. Joshi, N. Batra, J. Singh, and N. Birbian, “Association of mannose-binding lectin gene polymorphism with tuberculosis susceptibility and sputum conversion time,” International Journal of Immunogenetics, vol. 39, no. 1, pp. 10–14, 2012. View at Publisher · View at Google Scholar
  20. Z. B. Liu, R. J. Zheng, H. P. Xiao et al., “The correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of tuberculosis in 459 Han patients,” Zhonghua Jie He He Hu Xi Za Zhi, vol. 34, no. 12, pp. 923–928, 2011. View at Google Scholar
  21. H. A. Solǧun, D. Taştemir, N. Aksaray, I. Inan, and O. Demirhan, “Polymorphisms in NRAMP1 and MBL2 genes and their relations with tuberculosis in Turkish children,” Tuberkuloz ve Toraks, vol. 59, no. 1, pp. 48–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. T. Denholm, E. S. McBryde, and D. P. Eisen, “Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis,” Clinical and Experimental Immunology, vol. 162, no. 1, pp. 84–90, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. O. P. Dossou-Yovo, C. Lapoumeroulie, M. Hauchecorne et al., “Variants of the mannose-binding lectin gene in the benin population: heterozygosity for the p.G57E allele may confer a selective advantage,” Human Biology, vol. 81, no. 5-6, pp. 899–909, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Alagarasu, P. Selvaraj, S. Swaminathan, S. Raghavan, G. Narendran, and P. R. Narayanan, “Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India,” Tuberculosis, vol. 87, no. 6, pp. 535–543, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Liu, F. Zhang, Z. T. Xin et al., “Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population,” International Journal of Tuberculosis and Lung Disease, vol. 10, no. 10, pp. 1098–1103, 2006. View at Google Scholar · View at Scopus
  26. P. Selvaraj, M. S. Jawahar, D. N. Rajeswari, K. Alagarasu, M. Vidyarani, and P. R. Narayanan, “Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis,” FEMS Immunology and Medical Microbiology, vol. 46, no. 3, pp. 433–437, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. M. I. García-Laorden, M. J. Pena, J. A. Caminero et al., “Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population,” Molecular Immunology, vol. 43, no. 14, pp. 2143–2150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. H. M. El Sahly, R. A. Reich, S. J. Dou, J. M. Musser, and E. A. Graviss, “The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups,” Scandinavian Journal of Infectious Diseases, vol. 36, no. 2, pp. 106–108, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Søborg, H. O. Madsen, A. B. Andersen, T. Lillebaek, A. Kok-Jensen, and P. Garred, “Mannose-binding lectin polymorphisms in clinical tuberculosis,” Journal of Infectious Diseases, vol. 188, no. 5, pp. 777–782, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. M. I. García-Laorden, A. Manzanedo, A. Figuerola, F. Sánchez-García, and C. Rodríguez-Gallego, “Mannose-binding lectin polymorphisms in a Canary Islands (Spain) population,” Genes and Immunity, vol. 2, no. 5, pp. 292–294, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Özbaş-Gerçeker, I. Tezcan, A. I. Berkel et al., “The effect of mannose-binding protein gene polymorphisms in recurrent respiratory system infections in children and lung tuberculosis,” Turkish Journal of Pediatrics, vol. 45, no. 2, pp. 95–98, 2003. View at Google Scholar · View at Scopus
  32. L. E. Mombo, C. Y. Lu, S. Ossari et al., “Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections,” Genes and Immunity, vol. 4, no. 5, pp. 362–367, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. A. V. S. Hill, “The immunogenetics of human infectious diseases,” Annual Review of Immunology, vol. 16, pp. 593–617, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Garred, C. Richter, A. B. Andersen et al., “Mannan-binding lectin in the sub-saharan HIV and tuberculosis epidemics,” Scandinavian Journal of Immunology, vol. 46, no. 2, pp. 204–208, 1997. View at Google Scholar · View at Scopus
  35. E. G. Hoal-van Helden, J. Epstein, T. C. Victor et al., “Mannose-binding protein B allele confers protection against tuberculous meningitis,” Pediatric Research, vol. 45, no. 4 I, pp. 459–464, 1999. View at Google Scholar · View at Scopus
  36. P. Selvaraj, P. R. Narayanan, and A. M. Reetha, “Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India,” Tubercle and Lung Disease, vol. 79, no. 4, pp. 221–227, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. J. C. Delgado, A. Baena, S. Thim, and A. E. Goldfeld, “Ethnic-specific genetic associations with pulmonary tuberculosis,” Journal of Infectious Diseases, vol. 186, no. 10, pp. 1463–1468, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. C. Flores, N. Maca-Meyer, J. A. Pérez, A. M. González, J. M. Larruga, and V. M. Cabrera, “A predominant European ancestry of paternal lineages from Canary Islanders,” Annals of Human Genetics, vol. 67, no. 2, pp. 138–152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Pinto, A. M. González, M. Hernández, J. M. Larruga, and V. M. Cabrera, “Genetic relationship between the Canary Islanders and their African and Spanish ancestors inferred from mitochondrial DNA sequences,” Annals of Human Genetics, vol. 60, no. 4, pp. 321–330, 1996. View at Google Scholar · View at Scopus
  40. F. M. Pinto, A. M. González, M. Hernández, J. M. Larruga, and V. M. Cabrera, “Sub-Saharan influence on the Canary Islands population deduced from G6PD gene sequence analysis,” Human Biology, vol. 68, no. 4, pp. 517–522, 1996. View at Google Scholar · View at Scopus
  41. E. Esteban, J. M. Dugoujon, E. Guitard et al., “Genetic diversity in Northern Spain (Basque Country and Cantabria): GM and KM variation related to demographic histories,” European Journal of Human Genetics, vol. 6, no. 4, pp. 315–324, 1998. View at Google Scholar · View at Scopus
  42. P. Sánchez-Velasco, J. Escribano de Diego, J. E. Paz-Miguel, G. Ocejo-Vinyals, and F. Leyva-Cobián, “HLA-DR, DQ nucleotide sequence polymorphisms in the Pasiegos (Pas valleys, Northern Spain) and comparison of the allelic and haplotypic frequencies with those of other European populations,” Tissue Antigens, vol. 53, no. 1, pp. 65–73, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Sánchez-Velasco, E. Gómez-Casado, J. Martínez-Laso et al., “HLA alleles in isolated populations from north Spain: origin of the basques and the ancient Iberians,” Tissue Antigens, vol. 61, no. 5, pp. 384–392, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Kato-Maeda, P. J. Bifani, B. N. Kreiswirth, and P. M. Small, “The nature and consequence of genetic variability within Mycobacterium tuberculosis,” Journal of Clinical Investigation, vol. 107, no. 5, pp. 533–537, 2001. View at Google Scholar · View at Scopus
  45. B. López, D. Aguilar, H. Orozco et al., “A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes,” Clinical and Experimental Immunology, vol. 133, no. 1, pp. 30–37, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Keicho, M. Hijikata, and S. Sakurada, “Human genetic susceptibility to tuberculosis,” Nihon Rinsho, vol. 69, no. 8, pp. 1363–1367, 2011. View at Google Scholar
  47. R. J. Wilkinson, “Human genetic susceptibility to tuberculosis: time for a bottom-up approach?” Journal of Infectious Diseases, vol. 205, no. 4, pp. 525–527, 2012. View at Publisher · View at Google Scholar
  48. J. L. Rowell, N. F. Dowling, W. Yu, A. Yesupriva, L. Zhang, and M. Gwinn, “Trends in population-based studies of human genetics in infectious diseases,” PloS ONE, vol. 7, no. 2, Article ID e25431, 2012. View at Publisher · View at Google Scholar
  49. T. Qidwai, F. Jamal, and M. Y. Khan, “DNA sequence variation and regulation of genes involved in pathogenesis of pulmonary tuberculosis,” Scandinavian Journal of Immunology, vol. 75, no. 6, pp. 568–587, 2012. View at Publisher · View at Google Scholar
  50. A. K. Azad, W. Sadee, and L. S. Schlesinger, “Innate immune gene polymorphisms in tuberculosis,” Infection and Immunity, vol. 80, no. 10, pp. 3343–3359, 2012. View at Publisher · View at Google Scholar