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Pulmonary Medicine
Volume 2012 (2012), Article ID 745483, 10 pages
http://dx.doi.org/10.1155/2012/745483
Review Article

Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis

1Departamento de Biologia, UFRPE, Dom Manoel de Medeiros, S/N, Dois Irmãos, 52171-900 Recife, PE, Brazil
2Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ), Avenida Professor Moraes Rego S/N, Cidade Universitária, Campus da UFPE, 50670-420 Recife, PE, Brazil
3Núcleo de Educação Física e Ciências do Esporte, Centro Acadêmico de Vitória, Universidade Federal de Pernanbuco (UFPE), Vitória de Santo Antão, PE, Brazil

Received 30 August 2012; Revised 31 October 2012; Accepted 5 November 2012

Academic Editor: José R. Lapa e Silva

Copyright © 2012 Yone Vila Nova Cavalcanti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control of the infection by mycobacteria, TNF-alpha seems to have a primordial function. This cytokine acts in synergy with IFN-gamma, stimulating the production of reactive nitrogen intermediates (RNIs), thus mediating the tuberculostatic function of macrophages, and also stimulating the migration of immune cells to the infection site, contributing to granuloma formation, which controls the disease progression. IFN-gamma is the main cytokine involved in the immune response against mycobacteria, and its major function is the activation of macrophages, allowing them to exert its microbicidal role functions. Different from TNF-alpha and IFN-gamma, IL-10 is considered primarily an inhibitory cytokine, important to an adequate balance between inflammatory and immunopathologic responses. The increase in IL-10 levels seems to support the survival of mycobacteria in the host. Although there is not yet conclusive studies concerning a clear dichotomy between Th1 and Th2 responses, involving protective immunity and susceptibility to the disease, respectively, we can suggest that the knowledge about this responses based on the prevailing cytokine profile can help to elucidate the immune response related to the protection against M. tuberculosis.