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Pulmonary Medicine
Volume 2013 (2013), Article ID 291375, 6 pages
http://dx.doi.org/10.1155/2013/291375
Research Article

Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism

1Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA
2Research Service, Department of Veterans Affairs Omaha-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA
3Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-7850, USA

Received 18 July 2013; Revised 1 October 2013; Accepted 2 October 2013

Academic Editor: Charlie Strange

Copyright © 2013 Joseph H. Sisson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites ( ). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; ). CF subjects had a trend toward lower EBC . Conclusion. We found an association between VCPT-stimulated clearance and exhaled levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism.