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PPAR Research
Volume 2008, Article ID 164163, 10 pages
http://dx.doi.org/10.1155/2008/164163
Review Article

PPAR- in Vascular Pathophysiology

Laboratory of Vascular Molecular Biology and Bioengineering, Institute of Cardiovascular Science and Diabetes Center, Peking University Health Science Center, Beijing 100191, China

Received 25 July 2008; Accepted 27 October 2008

Academic Editor: Francine M. Gregoire

Copyright © 2008 Nanping Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR- , / , and . PPAR- , play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR- is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR- on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR- may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.