Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- Agonist
Figure 3
PPAR-γ activation by (a) MBX-102 acid, (b)
rosiglitazone, and (c) pioglitazone in the presence of increasing human serum
albumin. Normalized reporter assay data were
calculated as the percentage of maximum signal as described in Figure 2. The
percentage of maximum signal for the curves representing 0 and 0.08% serum
albumin was calculated independently. The dose-response curves shown are from a
representative experiment. Values are EC50 (M) determined from 2–6 experiments and
shown as the mean ± SD.
