Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- Agonist
Figure 4
Activation of PPAR-γ by MBX-102 acid in the presence of
human serum compared to mouse and rat serum. Normalized reporter assay data
are expressed as the percentage of maximum signal as described in Figure 2. The
dose-response curves shown are from representative experiments. MBX-102 acid
activation of PPAR-γ in the presence of 10% (v/v) human (H),
mouse (M), or rat (R) serum. The dose-response curves shown are from a
representative experiment. Values are EC50 (M) determined from 3
experiments and shown as the mean ± SD. FC is the ratio of EC50s for human: rat or human: mouse (* = , ** = , *** = by ANOVA with
Tukey post hoc test).
