Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- Agonist
Figure 5
Displacement of NCOR corepressor peptide from PPAR-γ by MBX-102 acid in the presence of
human serum. MBX-102 acid induced displacement of NCOR corepressor peptide
from the human PPAR-γ ligand-binding domain in the presence
of human serum at 0, 10%, or 40% (v/v). Normalized FRET assay data are
expressed as the percentage of maximum signal (as described in Figure 2). The
dose-response curves shown are from a representative experiment. Values are IC50 (M) determined from 3 experiments and shown as the mean ± SD.
