PPAR Research / 2010 / Article / Fig 3

Review Article

Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease

Figure 3

Isoflavones activate the PPARγ promoter: cultured endothelial cells were transfected with plasmids containing the promoter response elements for PPARγ (PPRE) or PPRE-negative plasmids and then exposed to indicated isoflavones (1 μM) and vehicle controls. Data are expressed as fold of the control (i.e., relative to no isoflavone-treated cells) and are means ± SEM ( ). *Different from control, . They illustrate the ability of isoflavones to stimulate transcription of PPARγ-regulated genes. Genistein, daidzein, and biochanin A (4′-methoxygenistein) have promoter activities comparable to rosiglitazone (figure reproduced with permission by the Journal of Nutrition).

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.