PPAR Research / 2010 / Article / Fig 3

Review Article

Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease

Figure 3

Isoflavones activate the PPARγ promoter: cultured endothelial cells were transfected with plasmids containing the promoter response elements for PPARγ (PPRE) or PPRE-negative plasmids and then exposed to indicated isoflavones (1 μM) and vehicle controls. Data are expressed as fold of the control (i.e., relative to no isoflavone-treated cells) and are means ± SEM ( ). *Different from control, . They illustrate the ability of isoflavones to stimulate transcription of PPARγ-regulated genes. Genistein, daidzein, and biochanin A (4′-methoxygenistein) have promoter activities comparable to rosiglitazone (figure reproduced with permission by the Journal of Nutrition).
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