Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2010 (2010), Article ID 243643, 9 pages
http://dx.doi.org/10.1155/2010/243643
Review Article

PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease

McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA

Received 10 June 2010; Accepted 11 August 2010

Academic Editor: Chih-Hao Lee

Copyright © 2010 Purin Charoensuksai and Wei Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Panda, M. P. Antoch, B. H. Miller et al., “Coordinated transcription of key pathways in the mouse by the circadian clock,” Cell, vol. 109, no. 3, pp. 307–320, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Yang, K. Wang, O. Valladares, S. Hannenhalli, and M. Bucan, “Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex,” Genome Biology, vol. 8, no. 11, article no. R247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Teboul, F. Guillaumond, A. Gréchez-Cassiau, and F. Delaunay, “The nuclear hormone receptor family round the clock,” Molecular Endocrinology, vol. 22, no. 12, pp. 2573–2582, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Staels, “When the Clock stops ticking, metabolic syndrome explodes,” Nature Medicine, vol. 12, no. 1, pp. 54–55, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. E. Muller, “Circadian variation and triggering of acute coronary events,” American Heart Journal, vol. 137, no. 4, pp. S1–S8, 1999. View at Google Scholar · View at Scopus
  6. J. E. Muller, “Circadian variation in cardiovascular events,” American Journal of Hypertension, vol. 12, no. 2, pp. 35S–42S, 1999. View at Google Scholar · View at Scopus
  7. X. Yang, K. A. Lamia, and R. M. Evans, “Nuclear receptors, metabolism, and the circadian clock,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 72, pp. 387–394, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Teboul, A. Gréchez-Cassiau, F. Guillaumond, and F. Delaunay, “How nuclear receptors tell time,” Journal of Applied Physiology, vol. 107, no. 6, pp. 1965–1971, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Reppert and D. R. Weaver, “Coordination of circadian timing in mammals,” Nature, vol. 418, no. 6901, pp. 935–941, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Dardente and N. Cermakian, “Molecular circadian rhythms in central and peripheral clocks in mammals,” Chronobiology International, vol. 24, no. 2, pp. 195–213, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. C. H. Ko and J. S. Takahashi, “Molecular components of the mammalian circadian clock,” Human Molecular Genetics, vol. 15, no. 2, pp. R271–R277, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. P. Pando and P. Sassone-Corsi, “Signaling to the mammalian circadian clocks: in pursuit of the primary mammalian circadian photoreceptor,” Science"s STKE, vol. 2001, no. 107, article no. re16, 2001. View at Google Scholar · View at Scopus
  13. S. M. Reppert and D. R. Weaver, “Molecular analysis of mammalian circadian rhythms,” Annual Review of Physiology, vol. 63, pp. 647–676, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Li and J. D. Lin, “Molecular control of circadian metabolic rhythms,” Journal of Applied Physiology, vol. 107, no. 6, pp. 1959–1964, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. M. Siepka, S. H. Yoo, J. Park, C. Lee, and J. S. Takahashi, “Genetics and neurobiology of circadian clocks in mammals,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 72, pp. 251–259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Cermakian and D. B. Boivin, “The regulation of central and peripheral circadian clocks in humans,” Obesity Reviews, vol. 10, supplement 2, pp. 25–36, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer, and U. Albrecht, “The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors,” Genes and Development, vol. 24, no. 4, pp. 345–357, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. E. E. Zhang, A. C. Liu, T. Hirota et al., “A genome-wide RNAi screen for modifiers of the circadian clock in human cells,” Cell, vol. 139, no. 1, pp. 199–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Escher and W. Wahli, “Peroxisome proliferator-activated receptors: insight into multiple cellular functions,” Mutation Research, vol. 448, no. 2, pp. 121–138, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Yu and J. K. Reddy, “Transcription coactivators for peroxisome proliferator-activated receptors,” Biochimica et Biophysica Acta, vol. 1771, no. 8, pp. 936–951, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Desvergne and W. Wahli, “Peroxisome proliferator-activated receptors: nuclear control of metabolism,” Endocrine Reviews, vol. 20, no. 5, pp. 649–688, 1999. View at Google Scholar · View at Scopus
  22. X. Yang, M. Downes, R. T. Yu et al., “Nuclear receptor expression links the circadian clock to metabolism,” Cell, vol. 126, no. 4, pp. 801–810, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. J.-C. Fruchart, “Peroxisome proliferator-activated receptor-alpha (PPARα): at the crossroads of obesity, diabetes and cardiovascular disease,” Atherosclerosis, vol. 205, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Tiraby and D. Langin, “Conversion from white to brown adipocytes: a strategy for the control of fat mass?” Trends in Endocrinology and Metabolism, vol. 14, no. 10, pp. 439–441, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Oishi, H. Shirai, and N. Ishida, “CLOCK is involved in the circadian transactivation of peroxisome- proliferator-activated receptor α (PPARα) in mice,” Biochemical Journal, vol. 386, no. 3, pp. 575–581, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Canaple, J. Rambaud, O. Dkhissi-Benyahya et al., “Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor α defines a novel positive feedback loop in the rodent liver circadian clock,” Molecular Endocrinology, vol. 20, no. 8, pp. 1715–1727, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. K.-I. Nakamura, I. Inoue, S. Takahashi, T. Komoda, and S. Katayama, “Cryptochrome and period proteins are regulated by the CLOCK/BMAL1 gene: crosstalk between the PPARs/RXRα-regulated and CLOCK/BMAL1-regulated systems,” PPAR Research, Article ID 348610, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Gatfield, G. Le Martelot, C. E. Vejnar et al., “Integration of microRNA miR-122 in hepatic circadian gene expression,” Genes and Development, vol. 23, no. 11, pp. 1313–1326, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Shirai, K. Oishi, T. Kudo, S. Shibata, and N. Ishida, “PPARα is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders,” Biochemical and Biophysical Research Communications, vol. 357, no. 3, pp. 679–682, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Wang, G. Yang, Z. Jia et al., “Vascular PPARγ controls circadian variation in blood pressure and heart rate through Bmal1,” Cell Metabolism, vol. 8, no. 6, pp. 482–491, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Lemberger, R. Saladin, M. Vázquez et al., “Expression of the peroxisome proliferator-activated receptor α gene is stimulated by stress and follows a diurnal rhythm,” Journal of Biological Chemistry, vol. 271, no. 3, pp. 1764–1769, 1996. View at Publisher · View at Google Scholar · View at Scopus
  32. D. D. Patel, B. L. Knight, D. Wiggins, S. M. Humphreys, and G. F. Gibbons, “Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice,” Journal of Lipid Research, vol. 42, no. 3, pp. 328–337, 2001. View at Google Scholar · View at Scopus
  33. M. A. Stavinoha, J. W. RaySpellicy, M. L. Hart-Sailors, H. J. Mersmann, M. S. Bray, and M. E. Young, “Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids,” American Journal of Physiology, vol. 287, no. 5, pp. E878–E887, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Oishi, D. Uchida, and N. Ishida, “Circadian expression of FGF21 is induced by PPARα activation in the mouse liver,” FEBS Letters, vol. 582, no. 25-26, pp. 3639–3642, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Yagita, F. Tamanini, G. T. J. Van der Horst, and H. Okamura, “Molecular mechanisms of the biological clock in cultured fibroblasts,” Science, vol. 292, no. 5515, pp. 278–281, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. K.-A. Stokkan, S. Yamazaki, H. Tei, Y. Sakaki, and M. Menaker, “Entrainment of the circadian clock in the liver by feeding,” Science, vol. 291, no. 5503, pp. 490–493, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Damiola, N. Le Minli, N. Preitner, B. Kornmann, F. Fleury-Olela, and U. Schibler, “Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus,” Genes and Development, vol. 14, no. 23, pp. 2950–2961, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Dowell, J. E. Ishmael, D. Avram, V. J. Peterson, D. J. Nevrivy, and M. Leid, “Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor α interacting protein,” Journal of Biological Chemistry, vol. 274, no. 22, pp. 15901–15907, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Alenghat, K. Meyers, S. E. Mullican et al., “Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology,” Nature, vol. 456, no. 7224, pp. 997–1000, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. L. Yin and M. A. Lazar, “The orphan nuclear receptor Rev-erbα recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene,” Molecular Endocrinology, vol. 19, no. 6, pp. 1452–1459, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. M. C. Sugden, P. W. Caton, and M. J. Holness, “PPAR control: it's SIRTainly as easy as PGC,” Journal of Endocrinology, vol. 204, no. 2, pp. 93–104, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Puigserver and B. M. Spiegelman, “Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator,” Endocrine Reviews, vol. 24, no. 1, pp. 78–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Liu, S. Li, T. Liu, J. Borjigin, and J. D. Lin, “Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism,” Nature, vol. 447, no. 7143, pp. 477–481, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. M. C. Hunt, P. J. G. Lindquist, J. M. Peters, F. J. Gonzalez, U. Diczfalusy, and S. E. H. Alexson, “Involvement of the peroxisome proliferator-activated receptor α in regulating long-chain acyl-CoA thioesterases,” Journal of Lipid Research, vol. 41, no. 5, pp. 814–823, 2000. View at Google Scholar · View at Scopus
  45. T. Inagaki, P. Dutchak, G. Zhao et al., “Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21,” Cell Metabolism, vol. 5, no. 6, pp. 415–425, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Rodríguez De Fonseca, M. Navarro, R. Gómez et al., “An anorexic lipid mediator regulated by feeding,” Nature, vol. 414, no. 6860, pp. 209–212, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Fu, S. Gaetani, F. Oveisi et al., “Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α,” Nature, vol. 425, no. 6953, pp. 90–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. Y.-X. Wang, C.-H. Lee, S. Tiep et al., “Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity,” Cell, vol. 113, no. 2, pp. 159–170, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Cameron, “The metabolic syndrome: validity and utility of clinical definitions for cardiovascular disease and diabetes risk prediction,” Maturitas, vol. 65, no. 2, pp. 117–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. X. Yang, Y.-K. J. Zhang, N. Esterly, C. D. Klaassen, and Y.-J. Y. Wan, “Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock,” Journal of Biochemistry, vol. 145, no. 5, pp. 609–623, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. X. Yang, M. Guo, and Y.-J.Y. Wan, “Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRα-deficient mouse livers,” American Journal of Pathology, vol. 176, no. 2, pp. 733–743, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. J. A. Ripperger, I. Schmutz, and U. Albrecht, “PERsuading nuclear receptors to dance the circadian rhythm,” Cell Cycle, vol. 9, no. 13, pp. 2515–2521, 2010. View at Google Scholar
  53. H. H. Steineger, H. N. Sorensen, J. D. Tugwood, S. Skrede, O. Spydevold, and K. M. Gautvik, “Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxismal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription,” European Journal of Biochemistry, vol. 225, no. 3, pp. 967–974, 1994. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Lemberger, B. Staels, R. Saladin, B. Desvergne, J. Auwerx, and W. Wahli, “Regulation of the peroxisome proliferator-activated receptor α gene by glucocorticoids,” Journal of Biological Chemistry, vol. 269, no. 40, pp. 24527–24530, 1994. View at Google Scholar · View at Scopus