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PPAR Research
Volume 2010, Article ID 530265, 6 pages
http://dx.doi.org/10.1155/2010/530265
Research Article

Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPAR ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats

1School of Science, Monash University, Sunway Campus, 46150, Bandar Sunway, Malaysia
2School of Medicine and Health Sciences, Monash University, Sunway Campus, 46150, Bandar Sunway, Malaysia

Received 30 May 2009; Accepted 28 August 2009

Academic Editor: Joshua K. Ko

Copyright © 2010 Chia Yoke Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Studies on ligand binding potential of glycyrrhizic acid, a potential agonist to PPAR , displayed encouraging results in amelioration of metabolic syndrome. The regulation of gene cassettes by PPAR affects glucose homeostasis, lipid, lipoprotein metabolism and adipogenesis. This study was performed to determine the effects of GA on total PPAR and LPL expression levels, lipid parameters and HOMA-IR. Oral administration of 100 mg/kg GA for 24 hours resulted in an increase in insulin sensitivity with decreases in blood glucose, serum insulin and HOMA-IR. Improvement in serum lipid parameters was also observed with a decrease in triacylglycerol, total cholesterol and LDL-cholesterol and an elevation in HDL-cholesterol. GA administration also resulted in up-regulation of total PPAR and LPL expression levels in the visceral and subcutaneous adipose tissues, abdominal and quadriceps femoris muscles, as well as liver and kidney, with a significant up-regulation only in the visceral adipose tissue, abdominal and quadriceps femoris muscles. Thus, oral administration of 100 mg/kg GA for 24 hours improved insulin sensitivity and lipid profiles and induced upregulation of total PPAR and LPL expression levels in all studied tissues.