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PPAR Research
Volume 2010, Article ID 542359, 11 pages
http://dx.doi.org/10.1155/2010/542359
Review Article

The Role of PPAR Activation in Liver and Muscle

1Institute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
2Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, 0316 Oslo, Norway

Received 1 May 2010; Accepted 12 July 2010

Academic Editor: J. Corton

Copyright © 2010 Lena Burri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PPAR is one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with PPAR target gene transcription, inasmuch as it can influence physiological homeostasis, including lipid and carbohydrate metabolism in various tissues. In this paper we summarize the involvement of PPAR in the metabolically active tissues liver and skeletal muscle and provide an overview of the risks and benefits of ligand activation of PPAR , with particular consideration to interspecies differences.