PPAR- Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice
Figure 3
No histological alteration was observed in the colon section from sham-operated mice (a). Mucosal injury was produced after DNBS administration characterized by absence of epithelium and a massive mucosal and submucosal infiltration of inflammatory cells (b). Treatment with VB corrected the disturbances in morphology associated with DNBS administration in PPAR-WT (c). The absence of PPAR- gene significantly increases the extent and severity of the histological signs of colon injury (d). The genetic absence of the PPAR- receptor significantly reduced the effect of the VB treatment (e). The histological score (f) was made by two independent observers. Figure 3 is representative of at least 3 experiments performed on different experimental days. Data are means ± SEM of 10 mice for each group. * versus Sham; ° versus DNBS-WT group.
