PPAR-𝛼 Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice

Figure 4

Role of PPAR-$\alpha$ in the anti-inflammatory property of VB on colon weight and body weight lost. Four days after DNBS administration a significant increase in colon weight (a) and body weight lost (b) was observed. Treatment with VB significantly reduced the increased colon weight and lowered body weight lost. The absence of PPAR-$\alpha \hspace{0.17em}\hspace{0.17em}$ gene significantly abolished the effect of VB. Figure 4 is representative of all the animals in each group. Data are means $\pm$ SEM of 10 mice for each group. *$P<.01\hspace{0.17em}\hspace{0.17em}$versus Sham; °$P<.01$ versus DNBS-WT group.

(a)

(b)