Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2012, Article ID 219319, 12 pages
http://dx.doi.org/10.1155/2012/219319
Research Article

Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury

1Medizinische Klinik und Poliklinik I, Nephrologie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany
2Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany
3Klinik für Anästhesie und Operative Intensivmedizin, Universitätsklinikum Halle (Saale), 06120 Halle (Saale), Germany

Received 20 September 2011; Accepted 3 November 2011

Academic Editor: Paul Drew

Copyright © 2012 Boris Betz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” Journal of Clinical Investigation, vol. 114, no. 1, pp. 5–14, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. J. V. Bonventre and J. M. Weinberg, “Recent advances in the pathophysiology of ischemic acute renal failure,” Journal of the American Society of Nephrology, vol. 14, no. 8, pp. 2199–2210, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. M. S. Goligorsky, S. V. Brodsky, and E. Noiri, “Nitric oxide in acute renal failure: NOS versus NOS,” Kidney International, vol. 61, no. 3, pp. 855–861, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Schneider, U. Raff, N. Vornberger et al., “L-arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats,” Kidney International, vol. 64, no. 1, pp. 216–225, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Schneider, C. Sauvant, B. Betz et al., “Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats,” The American Journal of Physiology, vol. 292, no. 5, pp. F1599–F1605, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Schramm, M. La, E. Heidbreder et al., “L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation,” Kidney International, vol. 61, no. 4, pp. 1423–1432, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Foglieni, A. Fulgenzi, P. Ticozzi et al., “Protective effect of EDTA preadministration on renal ischemia,” BMC Nephrology, vol. 7, article 5, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Chen, B. Xing, X. Liu et al., “Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide,” Journal of Surgical Research, vol. 149, no. 2, pp. 287–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. Goligorsky, S. V. Brodsky, and E. Noiri, “NO bioavailability, endothelial dysfunction, and acute renal failure: new insights into pathophysiology,” Seminars in Nephrology, vol. 24, no. 4, pp. 316–323, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Iglesias and J. J. Diéz, “Peroxisome proliferator-activated receptor gamma agonists in renal disease,” European Journal of Endocrinology, vol. 154, no. 5, pp. 613–621, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Sivarajah, P. K. Chatterjee, N. S. A. Patel et al., “Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury,” The American Journal of Nephrology, vol. 23, no. 4, pp. 267–276, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. P. K. Chatterjee, N. S. A. Patel, S. Cuzzocrea et al., “The cyclopentenone prostaglandin 15-deoxy-Δ12,14- prostaglandin J2 ameliorates ischemic acute renal failure,” Cardiovascular Research, vol. 61, no. 3, pp. 630–643, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Cuzzocrea, B. Pisano, L. Dugo et al., “Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces the development of nonseptic shock induced by zymosan in mice,” Critical Care Medicine, vol. 32, no. 2, pp. 457–466, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Shiojiri, K. Wada, A. Nakajima et al., “PPARγ ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice,” European Journal of Pharmacology, vol. 448, no. 2-3, pp. 231–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Folch-Puy, S. Granell, J. L. Iovanna, M. Barthet, and D. Closa, “Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats,” World Journal of Gastroenterology, vol. 12, no. 40, pp. 6458–6463, 2006. View at Google Scholar · View at Scopus
  16. A. T. Gonon, A. Bulhak, F. Labruto, P. O. Sjöquist, and J. Pernow, “Cardioprotection mediated by rosiglitazone, a peroxisome proliferator activated receptor gamma ligand,in relation to nitric oxide,” Basic Research in Cardiology, vol. 102, no. 1, pp. 80–89, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Cañuelo, E. Siles, R. Martínez-Romero, M. A. Peinado, and E. Martínez-Lara, “The nitric oxide system response to hypoxia/reoxygenation in the aged cerebral cortex,” Experimental Gerontology, vol. 42, no. 12, pp. 1137–1145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. U. Raff, R. Schneider, S. Gambaryan et al., “L-arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats,” Nephron Physiology, vol. 101, no. 3, pp. p39–p50, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Schick, T. J. Isbary, N. Schlegel et al., “The impact of crystalloid and colloid infusion on the kidney in rodent sepsis,” Intensive Care Medicine, vol. 36, no. 3, pp. 541–548, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Song, M. A. Knepper, X. Hu, J. G. Verbalis, and C. A. Ecelbarger, “Rosiglitazone activates renal sodium- and water-reabsorptive pathways and lowers blood pressure in normal rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 308, no. 2, pp. 426–433, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Schwartz, M. Mendonca, I. Schwartz et al., “Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats,” Journal of Clinical Investigation, vol. 100, no. 2, pp. 439–448, 1997. View at Google Scholar · View at Scopus
  22. V. Müller, G. Losonczy, U. Heemann et al., “Sexual dimorphism in renal ischemia-reperfusion injury in rats: possible role of endothelin,” Kidney International, vol. 62, no. 4, pp. 1364–1371, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Bachmakov, H. Glaeser, M. F. Fromm, and J. König, “Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1,” Diabetes, vol. 57, no. 6, pp. 1463–1469, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. G. Kim, H. N. Yang, H. W. Kim, S. K. Jo, W. Y. Cho, and H. K. Kim, “IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity,” Journal of Korean Medical Science, vol. 25, no. 4, pp. 557–563, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. P. K. Chatterjee, N. S. A. Patel, A. Sivarajah et al., “GW274150, a potent and highly selective inhibitor of iNOS reduces experimental renal ischemia/reperfusion injury,” Kidney International, vol. 63, no. 3, pp. 853–865, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Ling, C. Edelstein, P. Gengaro et al., “Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice,” The American Journal of Physiology, vol. 277, no. 3, pp. F383–F390, 1999. View at Google Scholar · View at Scopus
  27. G. L. Volti, V. Sorrenti, P. Murabito et al., “Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury,” Transplantation Proceedings, vol. 39, no. 10, pp. 2986–2991, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Du, Q. Guan, H. Diao, Z. Yin, and A. M. Jevnikar, “Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8,” The American Journal of Physiology, vol. 290, no. 5, pp. F1044–F1054, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Sauvant, R. Schneider, H. Holzinger, S. Renker, C. Wanner, and M. Gekle, “Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia,” Cellular Physiology and Biochemistry, vol. 24, no. 5-6, pp. 567–576, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Wessells, T. H. Teal, I. P. Luttrell, and C. J. Sullivan, “Effect of endothelial cell-based iNOS gene transfer on cavernosal eNOS expression and mouse erectile responses,” International Journal of Impotence Research, vol. 18, no. 5, pp. 438–445, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Ye, Y. Lin, S. Atar et al., “Myocardial protection by pioglitazone, atorvastatin, and their combination: mechanisms and possible interactions,” The American Journal of Physiology, vol. 291, no. 3, pp. H1158–H1169, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Wakino, K. Hayashi, S. Tatematsu et al., “Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats,” Hypertension Research, vol. 28, no. 3, pp. 255–262, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Komurai, Y. Ishii, F. Matsuoka et al., “Role of nitric oxide synthase activity in experimental ischemic acute renal failure in rats,” Molecular and Cellular Biochemistry, vol. 244, no. 1-2, pp. 129–133, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Bachmann and P. Mundel, “Nitric oxide in the kidney: synthesis, localization, and function,” The American Journal of Kidney Diseases, vol. 24, no. 1, pp. 112–129, 1994. View at Google Scholar · View at Scopus
  35. J. A. Polikandriotis, L. J. Mazzella, H. L. Rupnow, and C. M. Hart, “Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 9, pp. 1810–1816, 2005. View at Google Scholar
  36. J. G. Boyle, P. J. Logan, M. A. Ewart et al., “Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase,” Journal of Biological Chemistry, vol. 283, no. 17, pp. 11210–11217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. W. H. Fong, H. D. Tsai, Y. C. Chen, J. S. Wu, and T. N. Lin, “Anti-apoptotic actions of ppar-γ against ischemic stroke,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 180–186, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. D. L. Feinstein, A. Spagnolo, C. Akar et al., “Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?” Biochemical Pharmacology, vol. 70, no. 2, pp. 177–188, 2005. View at Publisher · View at Google Scholar · View at Scopus