PPAR Research

PPAR Research / 2014 / Article
Special Issue

PPARs and Metabolic Syndrome

View this Special Issue

Editorial | Open Access

Volume 2014 |Article ID 832606 | 2 pages | https://doi.org/10.1155/2014/832606

PPARs and Metabolic Syndrome

Received25 Feb 2014
Accepted25 Feb 2014
Published24 Mar 2014

Peroxisome proliferator-activated receptors (PPARs) exert versatile biological effects, notably in energy metabolism. During the last two decades, numerous studies have demonstrated that PPARs act as pivotal regulators of metabolic syndrome, a series of disorders in energy utilization and storage that are implicated with type 2 diabetes, diabetic nephropathy, and cardiovascular diseases, to mention a few. PPARα and PPARγ are the molecular targets of a number of marketed drugs for the treatment of these diseases, and accumulating evidence suggested PPARβ/δ as a potential therapeutic drug target as well. Although energy metabolism and metabolic syndrome are the most intensively studied domain of PPARs, it has not been addressed specifically in any issue of PPAR Research ever since its launch. Here, we gathered 3 reviews and 5 research articles that encompass metabolic syndrome and its complications.

M. Aprile et al. tackled the subject of PPARγ and human adipogenesis in their research article. Rather than focusing on canonical PPARγ transcripts, authors largely emphasized on the critical contribution of PPARγ dominant negative isoforms to adipogenesis and their implied potential role in pathological conditions. In addition, a novel of PPARγ dominant negative transcript, γ1ORF4, was first identified in this study. In regard to nonalcoholic fatty liver diseases, the hepatic expression of the metabolic syndrome, M. Sharif et al. conducted a thorough analysis of previously published data about the steatogenic role of PPARγ and summarized two probable PPARγ ligand-dependent toxicological modes of action: (i) activation of PPARγ in hepatocytes and (ii) inhibition in adipocytes.

Two papers, one review and a research article, by Z. Jia and Y. Sun et al., appraised the role of PPARγ in diabetic nephropathy (DN). Their comprehensive review summarized the limitations of traditional PPARγ agonists, addressed the advantages of newly developed PPARγ agonists, and rendered new insights into the therapeutic potential of PPARγ agonists in the treatment of DN, while the research article suggested that a combination of PPARγ agonists with COX-2/PGE2 inhibitors may be an alternative way of dealing with DN. In another research article, J. Jin et al. analyzed the correlation between PPAR gene polymorphisms and pediatric primary nephrotic syndrome (PNS) by comparing children with PNS against healthy subjects. They found that PPARγ (Pro12Ala) and PGC-1α (Gly482Ser) polymorphisms are associated with abnormal insulin and triglyceride metabolism in pediatric PNS patients, suggesting that these polymorphisms may be relevant to the prognosis of this chronic disease.

The knowledge of the role of PPARα in metabolic disorder-associated cardiovascular diseases was well recognized in this special issue. Z. Jia et al.’s research article asserted the involvement of HMGB1 (high mobility group box 1) in the protective effect of PPARα in cardiac hypertrophy and provided a novel approach to study the pathogenesis of cardiac hypertrophy. Although most studies showed that PPARα activation confers protection against atherogenesis, the intriguing possibility that PPARα might foster atherogenesis is also considered. In this current issue, M. Vechoropoulos et al. found that PPARα mediates the proatherogenic effect of chronic nitric oxide synthesis inhibition and this effect is independent of blood pressure and serum lipids alterations. These data further shaped the view that the role of PPARα in atherosclerosis needs to be reevaluated.

Lastly, in the review article “PPARs Integrate the Mammalian Clock and Energy Metabolism,” we collected recent findings about the role of PPARs in biological clocks. This brand new function of PPARs bridges energy metabolism with circadian rhythm whose relationship has been known for long time, but not well understood. We summarized the circadian function of three PPAR subtypes one by one and concluded that the abnormality of PPARs and circadian rhythm could impinge on each other and thus leads to metabolic disorders. Further investigation of PPARs in this field will give us a new perspective on the therapeutic advances in the treatment of metabolic ailments.

In conclusion, this special issue is packed with intriguing novel breakthroughs and insights into PPARs and metabolic syndrome. We hope that these advances will generate more interest from the scientific community in better understanding of the role of PPARs in metabolic syndrome and associated complications.

Lihong  Chen
Zhanjun  Jia
Guangrui  Yang

Copyright © 2014 Lihong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

1293 Views | 573 Downloads | 8 Citations
 PDF  Download Citation  Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.