PPAR Research

PPARs and Metabolic Syndrome


Publishing date
14 Mar 2014
Status
Published
Submission deadline
25 Oct 2013

Lead Editor

1Institute for Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA

2Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA

3Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA


PPARs and Metabolic Syndrome

Description

Metabolic syndrome is a cluster of metabolic abnormalities, including insulin resistance, glucose intolerance, obesity, hypertension, and dyslipidemia. People with metabolic syndrome have increased risks to develop type 2 diabetes, stroke, and cardiovascular diseases. The pathophysiologic mechanism underlying metabolic syndrome involves a complex interaction of crucial factors. Accumulating evidence suggests that metabolic nuclear receptors including peroxisome proliferator-activated receptors (PPARs) play important roles in metabolic syndrome. Many PPAR agonists have been used for the treatment of metabolic syndrome and the related complications. Activation of PPARs increases insulin sensitivity, reduces blood glucose, lowers blood pressure, decreases circulating lipids, and attenuates atherosclerosis in both human and mouse models.

In this special issue, we would like to invite authors to submit original research articles as well as review articles that focus on understanding the relationship between PPAR family and metabolic syndrome. Potential topics include, but are not limited to:

  • PPARs and type 2 diabetes and diabetic nephropathy
  • PPARs and obesity
  • PPARs and dyslipidemia
  • PPARs and blood pressure regulation
  • PPARs and atherosclerosis and other cardiometabolic diseases
  • Genetic polymorphisms of PPARs and metabolic diseases
  • Potential therapies of PPAR ligands for metabolic syndrome
  • Toxicology and clinical safety profile of PPAR ligands

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ppar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ppar/meta/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 832606
  • - Editorial

PPARs and Metabolic Syndrome

Lihong Chen | Zhanjun Jia | Guangrui Yang
  • Special Issue
  • - Volume 2014
  • - Article ID 537865
  • - Research Article

PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms

M. Aprile | M. R. Ambrosio | ... | A. Ciccodicola
  • Special Issue
  • - Volume 2014
  • - Article ID 432647
  • - Review Article

Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease

Merilin Al Sharif | Petko Alov | ... | Ivanka Tsakovska
  • Special Issue
  • - Volume 2014
  • - Article ID 653017
  • - Review Article

PPARs Integrate the Mammalian Clock and Energy Metabolism

Lihong Chen | Guangrui Yang
  • Special Issue
  • - Volume 2014
  • - Article ID 818530
  • - Review Article

New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy

Zhanjun Jia | Ying Sun | ... | Yue Zhang
  • Special Issue
  • - Volume 2014
  • - Article ID 124583
  • - Research Article

The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα

Michal Vechoropoulos | Maya Ish-Shalom | ... | Karen M. Tordjman
  • Special Issue
  • - Volume 2014
  • - Article ID 541394
  • - Research Article

HMGB1 Is Involved in the Protective Effect of the PPARα Agonist Fenofibrate against Cardiac Hypertrophy

Zhankui Jia | Rui Xue | ... | Quancheng Kan
  • Special Issue
  • - Volume 2013
  • - Article ID 612971
  • - Research Article

PPAR Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice

Ying Sun | Zhanjun Jia | ... | Tianxin Yang
  • Special Issue
  • - Volume 2013
  • - Article ID 927915
  • - Research Article

Correlation between PPAR Gene Polymorphisms and Primary Nephrotic Syndrome in Children

Jiaping Jin | Guixia Ding | ... | Aihua Zhang
PPAR Research
 Journal metrics
Acceptance rate44%
Submission to final decision48 days
Acceptance to publication38 days
CiteScore7.100
Impact Factor2.953
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